Occurrence of Chiral Bioactive Compounds in the Aquatic Environment: A Review

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Cláudia Ribeiro (Autor) Outra; Ana Rita Ribeiro (Autor) FEUP; Alexandra S. Maia (Autor) Outra; Maria Elizabeth Tiritan (Autor) FFUP

Revista

Título: Symmetry

Vol. 9 Nº 10

Páginas: 1-33

ISSN: 2073-8994

Editora: MDPI

Indexação

ISI Web of Knowledge - 21 Citações

Scopus - 26 Citações

Outras Informações

ID Authenticus: P-00N-47S

DOI: 10.3390/sym9100215

Abstract (EN): In recent decades, the presence of micropollutants in the environment has been extensively studied due to their high frequency of occurrence, persistence and possible adverse effects to exposed organisms. Concerning chiral micropollutants in the environment, enantiomers are frequently ignored and enantiomeric composition often neglected. However, enantioselective toxicity is well recognized, highlighting the need to include enantioselectivity in environmental risk assessment. Additionally, the information about enantiomeric fraction (EF) is crucial since it gives insights about: (i) environmental fate (i.e., occurrence, distribution, removal processes and (bio)degradation); (ii) illicit discharges; (iii) consumption pattern (e.g., illicit drugs, pharmaceuticals used as recreational drugs, illicit use of pesticides); and (iv) enantioselective toxicological effects. Thus, the purpose of this paper is to provide a comprehensive review about the enantioselective occurrence of chiral bioactive compounds in aquatic environmental matrices. These include pharmaceuticals, illicit drugs, pesticides, polychlorinated biphenyls (PCBs) and polycyclic musks (PCMs). Most frequently analytical methods used for separation of enantiomers were liquid chromatography and gas chromatography methodologies using both indirect (enantiomerically pure derivatizing reagents) and direct methods (chiral stationary phases). The occurrence of these chiral micropollutants in the environment is reviewed and future challenges are outlined.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 33