Molecular Markers: Y chromosome

Code:

B4034

Acronym:

B4034

Keywords
Classification	Keyword
OFICIAL	Biology

Instance: 2013/2014 - 2S

Active?	Yes
Responsible unit:	Department of Biology
Course/CS Responsible:	Master in Forensic Genetics

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
M:GF	9	plano de estudos do Mestrado em Genética Forense a partir de 2013_2014.	1	-	6	42	162

Teaching language

Suitable for English-speaking students

Objectives

To master the use of Y chromosome (non-recombining) genetic markers in the forensic context

Learning outcomes and competences

mastering the use of Y chromosome specific genetic markers in forensic context

Working method

Presencial

Program

Evolution of sex chromosomes: differentiation and structure of Y chromosome
Y chromosome specific region: comparison with other primates: structure and evolution.
Y chromosome specific markers: STRs e SNPs.
Transmission properties of Y chromosome.
Usefulness of Y chromosome specific markers in paternity investigation and forensic identification: examples and likelihood ratio (LR) calculations
Y-STR databases: haplotype frequencies, sufficiency and sample size, population substructure
Y-STRs mutations: polymorphisms vs. germinal mutations. Factors influencing Y-STRs mutation rate: number of repeats, type of mutation (gains and losses according to allele length), age.
Y chromosome genetic diversity in human populations: Y chromosome lineages phylogeny and worldwide distribution.
Male DNA of unknown provenance: ascertainment of population of origin through Y-STRs typing.

Mandatory literature

John M. Butler ; Forensic DNA typing. Biology, technology and genetics of STR markers
Jobling, M.A., M.E. Hurles, and C. Tyler-Smith; Human Evolutionary Genetics Origins, Peoples & Disease
Gusmão L, Alves C ; Y chromosome STR typing. In Forensic DNA Typing Protocols, v.297 (Carracedo A., ed.), Humana Press Inc., Totowa, New Jersey, pp. 67-81.
Gusmão L, Brión M, Gomes I ; The human Y chromosome male specific polymorphisms and forensic genetics. In Handbook of Analytical separation. Vol. 6. Forensic Sciences. MJ Bogusz and R Smith (eds.). Elsevier Science. Amsterdam.
Karafet, T.M., et al. ; New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree. Genome Res, 18(5): p. 830-8.

Teaching methods and learning activities

lectures and practical lessons

Evaluation Type

Evaluation with final exam

Assessment Components

designation	Weight (%)
Exame	100,00
Total:	100,00

Eligibility for exams

participation in the lectures and practical lessons

Calculation formula of final grade

not applicable

Examinations or Special Assignments

presentation of a report

Special assessment (TE, DA, ...)

not applicable

Classification improvement

not applicable