Orbitostriatal encoding of reward delayed gratification and impulsivity in chronic pain

• Type: Article in International Scientific Journal
• Date: 2024-05-28

Authors

Mariana Cerqueira-Nunes (Author) FMUP; Clara Monteiro (Author) FMUP; Vasco Galhardo (Author) FMUP; Helder Cardoso-Cruz (Author) FMUP

Journal

Title: Brain Research

Vol. 1839 No. 149044

ISSN: 0006-8993

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Scientific classification

CORDIS: Health sciences ; Health sciences > Neuroscience

FOS: Medical and Health sciences > Basic medicine

Associated Projects

MEMORYSTIM - Modulação optogenética da sinalização GABAérgica e dopaminérgica do córtex préfrontal para a reversão de défices cognitivos relacionados com dor crónica

2022.05193.PTDC - Circuitos dopaminérgicos de codificação de hábitos e dependência em modelos animais de dor crónica

POCI-01-0145-FEDER-028498 - Codificação de sinais de recompensa em populações neuronais do circuito dopaminérgico: estudo optogenético dos correlatos neuronais de decisão e expectativa

Other information

Authenticus ID: P-010-GF6

DOI: 10.1016/j.brainres.2024.149044

Abstract (EN): Central robust network functional rearrangement is a characteristic of several neurological conditions, including chronic pain. Preclinical and clinical studies have shown the importance of pain-induced dysfunction in both orbitofrontal cortex (OFC) and nucleus accumbens (NAc) brain regions for the emergence of cognitive deficits. Outcome information processing recruits the orbitostriatal circuitry, a pivotal pathway regarding contextdependent reward value encoding. The current literature reveals the existence of structural and functional changes in the orbitostriatal crosstalk in chronic pain conditions, which have emerged as a possible underlying cause for reward and time discrimination impairments observed in individuals affected by such disturbances. However, more comprehensive investigations are needed to elucidate the underlying disturbances that underpin disease development. In this review article, we aim to provide a comprehensive view of the orbitostriatal mechanisms underlying time-reward dependent behaviors, and integrate previous findings on local and network malplasticity under the framework of the chronic pain sphere.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8