Retinal Drug Delivery: Rethinking Outcomes for the Efficient Replication of Retinal Behavior

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Souto, EB (Author) Other; Sanchez Lopez, E (Author) Other; Campos, JR (Author) Other; da Ana, R (Author) Other; Espina, M (Author) Other; Garcia, ML (Author) Other; Severino, P (Author) Other; Batain, F (Author) Other; Alves, TFR (Author) Other; Crescencio, KMM (Author) Other; Souto, SB (Author) FMUP; Chaud, MV (Author) Other

Journal

Title: Applied Sciences

Vol. 10

Final page: 4258

Publisher: MDPI

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00S-EWA

DOI: 10.3390/app10124258

Abstract (EN): The retina is a highly organized structure that is considered to be "an approachable part of the brain." It is attracting the interest of development scientists, as it provides a model neurovascular system. Over the last few years, we have been witnessing significant development in the knowledge of the mechanisms that induce the shape of the retinal vascular system, as well as knowledge of disease processes that lead to retina degeneration. Knowledge and understanding of how our vision works are crucial to creating a hardware-adaptive computational model that can replicate retinal behavior. The neuronal system is nonlinear and very intricate. It is thus instrumental to have a clear view of the neurophysiological and neuroanatomic processes and to take into account the underlying principles that govern the process of hardware transformation to produce an appropriate model that can be mapped to a physical device. The mechanistic and integrated computational models have enormous potential toward helping to understand disease mechanisms and to explain the associations identified in large model-free data sets. The approach used is modulated and based on different models of drug administration, including the geometry of the eye. This work aimed to review the recently used mathematical models to map a directed retinal network.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 25