The role of Helicobacter pylori infection in the web of gastric cancer causation

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

peleteiro, b (Author) FMUP; La Vecchia, C (Author) Other; Lunet N (Author) FMUP

Journal

Title: European Journal of Cancer Prevention

Vol. 21

Pages: 118-125

ISSN: 0959-8278

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 70 Citations

Scopus - 77 Citations

Other information

Authenticus ID: P-002-CWW

DOI: 10.1097/cej.0b013e32834a7f66

Abstract (EN): The decline in gastric cancer mortality is a major achievement in cancer control. It has been attributed to a set of factors related to the improvement of the populations' living conditions, namely the increase in the consumption of fruit and vegetables and the decrease in salt intake, and therefore labelled as an 'unplanned triumph'. In the last decades, however, we witnessed the gradual acceptance of Helicobacter pylori infection as the most important environmental factor contributing to the occurrence of gastric cancer. The potential for further reducing the burden of cancer by acting on a single modifiable exposure, that is, preventing or treating infection, and the extent to which it may be achieved, requires an in-depth knowledge of the contribution of H. pylori infection to the causal mechanisms leading to cancer. We propose a conceptual framework for the interpretation of the role of H. pylori infection in the web of gastric cancer causation, taking into account the nosological heterogeneity of gastric cancer, the induction period for the action of H. pylori infection and its potential role as a necessary component cause. European Journal of Cancer Prevention 21: 118-125 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8