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Comuta visibilidade da coluna esquerda
Você está em: Start > Project: POCI-01-0145-FEDER-016804 (PTDC/DTP-PIC/4104/2014)

Project: POCI-01-0145-FEDER-016804 (PTDC/DTP-PIC/4104/2014)

Project name: DIASTIFF - Modulation of myocardial diastolic stiffness by strech. New physiological mechanism, diagnostic and therapeutic implications in preserved ejection fraction heart failure.
Project code: POCI-01-0145-FEDER-016804 (PTDC/DTP-PIC/4104/2014)
Main Objective: Reforçar a investigação, o desenvolvimento tecnológico e a inovação
Intervention Region: Norte
Proposing institution/Lead promoter/Coordinating entity: Faculdade de Medicina da Universidade do Porto
Date of approval: 2016-05-10
Start date: 2016-07-01
Completion date: 2019-06-30
Eligible Cost of the Project
Total Eligible Cost: 184.212,00 EUR
Total Financial Support
União Europeia - FEDER: 156.580,20 EUR
Orçamento de Estado: 27.631,80 EUR
Financial Support to the University of Porto
Total of the University of Porto: 184.212,00 EUR
Nacional/Regional | União Europeia - FEDER | Faculdade de Medicina da Universidade do Porto: 184.212,00 EUR
Objectives, activities and expected/achieved results
Objetivos e Atividades
Our objectives are to:
1. thoroughly escribe and quantify the response to stretch in: (i) different experimental set-ups ranging from the in vitro (skinned cardiomyocytes), ex vivo tissue and organ level,to the in vivo intact organism, (ii) healthy and diseased animals from different species including a large animal model,and also (iii) cardiac surgical patients;
2. dissect the subcellular pathways underlying the diastolic response to stretch, focusing on the activities of PKG and CaMK II;
3. demonstrate that impaired PKG signalling is responsible for inefficient responses to stretch;
4. further establish the role of titin in the response;
5. evaluate the potential of myocardial stretch as a diagnostic tool in HFpEF in small and large animal models by performing haemodynamic stress experiments;
6. extend our findings from animal models to the patient (cardiac surgical patients);
7. evaluate the therapeutic potential of enhancing the PKG pathway in a preclinical trial;

Resultados Esperados/Atingidos
Avaliações em curso
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