Design of potential therapeutic peptides and carriers to inhibit amyloid beta peptide aggregation

• Type: Article in International Conference Proceedings Book
• Date: 2012

Authors

Joana A. Loureiro (Author) FEUP; Manuel A. N. Coelho (Author) FEUP; Sandra Rocha (Author) Other; Maria do Carmo Pereira (Author) FEUP

Conference proceedings International

Title: 2012 IEEE 2ND PORTUGUESE MEETING IN BIOENGINEERING (ENBENG)

Pages: 1-4

2nd IEEE Portuguese Meeting in Bioengineering (ENBENG)

Coimbra, PORTUGAL, FEB 23-25, 2012

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 3 Citations

INSPEC

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

Other information

Authenticus ID: P-002-F2G

DOI: 10.1109/enbeng.2012.6331364

Abstract (EN): The conformational changes and aggregation of amyloid beta peptide (A beta) are associated to Alzheimer's disease (AD). The aim of this work is to study the structure and fibril assembly of A beta in the presence of charged and nonionic amphiphiles, and beta-sheet breaker peptides/conjugates. It is expected that these molecules will inhibit A beta aggregation. Liposome systems will be developed as carriers for these peptide conjugates to cross the brain blood barrier (BBB).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4