Immunology
| Keywords |
| Classification |
Keyword |
| OFICIAL |
Medicine |
Instance: 2024/2025 - 1S (of 16-09-2024 to 10-01-2025) 
Cycles of Study/Courses
| Acronym |
No. of Students |
Study Plan |
Curricular Years |
Credits UCN |
Credits ECTS |
Contact hours |
Total Time |
| MIM |
196 |
Official Study Plan |
2 |
- |
6 |
56 |
162 |
Teaching Staff - Responsibilities
Teaching language
Portuguese
Objectives
1. Acquisition of knowledge on fundamental immunology, necessary for the understanding of the immune physiology and pathology in humans. 2. Acquisition of skills for a better understanding of basic and advanced bibliographic information in the area of immunology. 3. Acquisition of of skills for self-oriented study. 4. Improvement of communication skills regarding oral and written transmission of knowledge. 5. Improvement of laboratory skills. 6. Acquisition of skills and knowledge on specific immunological diagnostic techniques.
Learning outcomes and competences
1. Acquisition of knowledge on fundamental immunology, necessary for the understanding of the immune physiology and pathology in humans. 2. Acquisition of skills for a better understanding of basic and advanced bibliographic information in the area of immunology. 3. Acquisition of of skills for self-oriented study. 4. Improvement of communication skills regarding oral and written transmission of knowledge. 5. Improvement of laboratory skills. 6. Acquisition of skills and knowledge on specific immunological diagnostic techniques.
Working method
Presencial
Program
1. Introduction to the immune system. 1.1. General introduction to the immune system. 1.2. Overview of hematopoiesis 2. Innate Immunity 2.1. Effector mechanisms (phagocytic cells, complement, inflammation). 2.2. Pathogen-associated molecular patterns (PAMPs) and their recognition (PRRs). 3. Acquired immunity. Cellular and mollecular components of the immune system and antigen recognition. 3.1. Central and perypheral lymphiod organs. 3.2. MHC. Codification and antigen presentation. 3.3. Immunoglobulins. B-cell receptor (BCR). 3.4. Antigen-antibody reactions. 3.5. V(D)J recombination and generation of diversity in immunoglobulins and T-cell eceptor (TCR). Implications of this process in the diagnostisc of primary immunodrficiencies. 3.6. TCR, Structure and function. 4. Ontogeny and dinamics of lymphoid populations. 4.1. Ontogeny and activation of B-cells. 4.2. Maturation of T and NK cells. 4.3. Activation of T-cells and B-T-cell cooperation. 5. Effector Mechanisms. 5.1. Cytokines. Differentiation and effector and regulatory function of T-cells. 5.2. Immune response during infection.5.3. Immunity at body surfaces 5.4. Vaccines. 6. The immune system in physiological and pathologycal conditions. 6.1. Hypersensitivity reactions. 6.2. Tolerance and autoimmunity. 6.3. Transplantation. 6.4. Primary and secondary immunodeficiencies. 6.5. Tumor immunity and implications for immunotherapy. 7. Immunological methods 7.1. Separation of mononuclear cells 7.2. B-cell response to a mitogen. Measurement of serum immunoglobulins by using “Sandwich-ELISA”. 7.3.Flow cytometry 7.4. Immunopathology 7.5. Phagocytosis. 7.6. Discussion of clinical case studies.
Mandatory literature
Abul Abbas, Andrew Lichtman, Shiv Pillai; Cellular and Molecular Immunology, Elsevier, 2021. ISBN: 9780323757485
Teaching methods and learning activities
Theoretical classes. Laboratory classes and oral discussions
keywords
Health sciences > Medical sciences > Medicine > Immunology
Evaluation Type
Distributed evaluation with final exam
Assessment Components
| Designation |
Weight (%) |
| Exame |
100,00 |
| Total: |
100,00 |
Amount of time allocated to each course unit
| Designation |
Time (hours) |
| Estudo autónomo |
106,00 |
| Frequência das aulas |
56,00 |
| Total: |
162,00 |
Eligibility for exams
Attaining of a minimum of 3/4 of the laboratory classes is necessary.
Calculation formula of final grade
Mark obtained on final exam or average of two parcial exams A global mark of 9,5/20 is necessary for approval.
Examinations or Special Assignments
N/A
Internship work/project
N/A
Special assessment (TE, DA, ...)
The assessment is carried out by means of a final exam, which will have the same length and duration as the regular exam
Classification improvement
The grade improvement is carried out by means of a final exam, which will have the same length and duration as the regular exam.