Immunology and Infection

Code:

L.BIO045

Acronym:

IINF

Keywords
Classification	Keyword
OFICIAL	Basic Sciences (Mathematics, Physics, Chemistry, Biology)

Instance: 2023/2024 - 1S (of 11-09-2023 to 15-12-2023)

Active?	Yes
Responsible unit:	Imuno-Physiology and Pharmacology
Course/CS Responsible:	Bachelor in Bioengineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
L.BIO	32	Syllabus	3	-	6	39	162

Teaching language

Portuguese

Objectives

1. Acquisition of knowledge in basic or fundamental immunology, based on the understanding of physiology and immunological pathology in humans. 2. Acquisition of skills to understand basic and advanced bibliographic information in the subject area of immunology, with an emphasis on immunology of infection. 3. Acquisition of self-learning habits and methods. 4. Improvement of the ability to transmit information and knowledge orally and in writing. 5. Acquisition of knowledge about the fundamentals of some techniques used in immunological diagnosis.

Learning outcomes and competences

Knowledge about the immune system namely when faced with infectious agents. Ability to critically analyze and interpret scientific data and analytical results. Correct use of the field nomenclature.

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

Basic Microbiology, Biochemistry, Molecular Biology.

Program

1. Introduction to the immune system.
1.1. General introduction to the immune system.

2. Innate Immunity
2.1. Effector mechanisms (phagocytic cells, complement, inflammation).
2.2. Molecular patterns associated with pathogens (PAMPs) and their recognition (PRRs).

3. Acquired immunity. Structural, molecular and cellular components of the immune system and antigen recognition.
3.1. Central and peripheral lymphoid organs and lymphocyte development.
3.2. MHC. Antigenic coding and presentation.
3.3. Immunoglobulins and T cell receptor. Structure and coding.

4. Ontogenesis and dynamics of lymphocyte populations.
4.1. B cell maturation and differentiation
4.2. T cell maturation.
4.3.B and T cell activation and cooperation mechanisms between B cells and T cells.

5. Mechanisms for effecting and regulating the immune response.
5.1. Cytokines.
5.2. Polarization of T cells.
5.3. Immune response in situations of infection.
5.4. Contraction of the immune response
5.5. Immunity on body surfaces.
5.6. Vaccination.

6. The immune system under physiological and pathological conditions.
6.1. Hypersensitivity reactions.
6.2. Tolerance and autoimmunity.
6.3. Transplantation.
6.4. Immune response against tumors.

7. Immunoengineering
7.1. Interaction of the immune system with biomaterials.
7.2. immunoengineered-based immunotherapy and vaccination

Mandatory literature

Abul Abbas, Andrew Lichtman, Shiv Pillai; Cellular and Molecular Immunology, Elsevier, 2021. ISBN: 9780323757485

Complementary Bibliography

Kenneth M. Murphy, Casey Weaver, Leslie J. Berg; Janeway's Immunobiology , W. W. Norton & Company, 2022. ISBN: 978-0393884890

Comments from the literature

Students may choose between the textbooks suggested.

Teaching methods and learning activities

Lectures with discussion. 

keywords

Health sciences > Medical sciences > Medicine > Immunology
Health sciences > Medical sciences > Medicine > Infections

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	100,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Frequência das aulas	36,00
Estudo autónomo	126,00
Total:	162,00

Eligibility for exams

Attending the fraction of classess according to UP rules

Calculation formula of final grade

Final grade=mark in exam