Biological Chemistry I

Code:

MV117

Acronym:

QBI

Keywords
Classification	Keyword
OFICIAL	Basic Sciences

Instance: 2021/2022 - 1S (of 04-10-2021 to 14-01-2022)

Active?	Yes
Responsible unit:	Chemistry
Course/CS Responsible:	Integrated Masters Degree in Veterinary Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMV	91	Official Study Plan	1	-	6	70	162

Teaching language

Portuguese

Objectives

1. To rationalize living systems in terms of basic Chemistry principles. To present Biological Chemistry as a subset of Chemistry.

2. To correlate knowledge from Organic and Inorganic Chemistry with Biological Chemistry.

3. To aquire specific knowledge about biological molecules and and cellular chemistry organization.

Learning outcomes and competences

1. To have the basic concepts of Chemistry, except for chemical kinetics.

2. Ability to solve basic Chemistry problems.

3. Knowledge of the biologically important functional groups of carbon compounds and basic notions of conformation and stereochemistry.

Working method

Presencial

Program

Theoretical

1. Molecular structure Chemical bond models, stereoisomery, molecular conformation.

2. Bioenergetics Thermodynamics. Principles of thermodynamics. Gibbs function and chemical potential. Chemical equilibrium, application to Bronsted acid-base reactions. Energetics of redox reactions. Energetics of transport processes across biological membranes. Application of Thermodynamics Principles and Concepts to biological systems.

3. Bioinorganics Metalic elements in biological systems: properties and regulation.

4. Bioorganics Alkanes and cycloalkanes. Conformation and conformation analysis of alkanes and cycloalkanes. Conformation of cyclohexane. Reactions of free radicals. Alkenes: Stability of Alkenes. Addition Reactions. Stability of carbocations. Electrophiles and nucleophiles. Regioselective reactions. Stereochemistry and quiral molecules. Stereogenic carbons. Enantiomers and diastereoisomers. The R and S system. Optical activity. Fischer projection. Stereospecific reactions.

Laboratorial

1. Chemistry laboratory basic techniques

2. Cromatography

3. Calorimetry

4. Potenciometric titration

Mandatory literature

P. W. Atkins and Julio de Paula; Physical Chemistry for the Life Sciences 2nd Edition, W H Freeman & Co, 2011
D. L. Nelson and M.M.Cox; Principles of Biochemistry 6th Edition, Freeman, New York, 2013
T.W. GRAHAM SOLOMONS and CRAIG B. FRYHLE; Organic Chemistry 10th Edition, John Wiley & Son, 2011
Raymond Chang; Physical Chemistry for the Biosciences, University Science Books, Sausalito, 2005

Teaching methods and learning activities

Theoretical classes, using Powerpoint presentations. Theoretical-practical classes of problem solving and matters related with laboratorial works. Laboratorial classes where the students work in groups of up to 3, following a written protocol.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	100,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	92,00
Frequência das aulas	70,00
Total:	162,00

Eligibility for exams

Minimal presence in 75% of laboratorial and problem-solving classes.

Calculation formula of final grade

Final mark (F), available options:

Option 1: Partial assessments A3 and A4:
F = ( A1 + A2 ) / 2

Option 2: Exam E1:
F = E1

All assessments are composed of a theoretical evaluation (18 points) and a practical theoretical evaluation (2 points). Assessments A2 and E1 are simultaneous and mutually exclusive.

Observations

Students are not allowed to enter the classes 10 minutes after its beggining time. Adequate lab coats are mandatory in laboratorial classes.