Immunology

Code:

MV224

Acronym:

IM

Keywords
Classification	Keyword
OFICIAL	Basic Sciences

Instance: 2020/2021 - 2S

Active?	Yes
Responsible unit:	Imuno-Physiology and Pharmacology
Course/CS Responsible:	Integrated Masters Degree in Veterinary Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMV	60	Official Study Plan	2	-	5	56	135

Teaching language

Portuguese

Objectives

1. Acquisition of knowledge and skills on fundamental immunology, emphasizing the particular specificities of different domestic animals. 2. Acquisition of skills helpful for a better understanding of basic and advanced bibliographic information in the area of veterinary immunology. 3. Acquisition and development of rational mechanisms useful for the interpretation of immunological data and resolution of immunological problems. 4. Acquisition of skills for self-oriented study, including the correct usage of specific databases. 5. Improvement of communication skills regarding oral and written transmission of knowledge. 6. Acquisition of skills and knowledge on specific immunological diagnostic techniques. 7. Improvement of laboratory skills.

Learning outcomes and competences

Working method

Presencial

Program

1. Introduction to the immune system. 1.1. General introduction to the immune system.

2. Innate Immunity 2.1. Effector mechanisms (phagocytic cells, complement, inflammation). 2.2. Pathogen-associated molecular patterns (PAMPs) and their recognition (PRRs).

3. Adaptive immunity. Cellular and mollecular components of the immune system and antigen recognition. 3.1. Central and perypheral lymphiod organs. Diffuse lymphoid tissue. 3.2. Hematopoietic development. 3.3. Immunoglobulins. B-cell receptor (BCR). 3.4. Antigen-antibody reactions. 3.5. V(D)J recombination and generation of diversity in immunoglobulins and T-cell eceptor (TCR). 3.6. TCR, Structure and function. 3.7. MHC. Antigen presentation.

4. Ontogeny and dinamics of lymphoid populations. 4.1. Ontogeny and activation of B-cells. 4.2. Maturation of T and NK cells. 4.3. Activation of T-cells and B-T-cell cooperation. 4.4. Primary immunodeficiencies.

5. Effector and regulatory immune mechanisms. 5.1. Citokynes. Differentiation and effector and regulatory function of T-cells. 5.2. Immune response during infection. 5.3. Immunity in body surfaces 5.4. Vaccines.

6. The immune system in physiological and pathologycal conditions. 6.1. Hypersensitivity reactions. 6.2. Tumor immunology. 6.3. Tolerance and autoimmunity. 6.4. Transplantation. 

7. Immunological methods 7.1. Separation of blood mononuclear cells 7.2. Morphology of lymphoid organs. 7.3. Production of monoclonal antibodies. 7.4. B-cell response to a mitogen. Measurement of serum immunoglobulins by using “Sandwich-ELISA”. 7.5. Immunopathology. 7.6. Flow cytometry 7.7. Discussion of scientific data and clinical cases.

Mandatory literature

Tizard, Ian; veterinary Immunology, Saunders, 2017. ISBN: 9780323523493

Comments from the literature

Scientific articles may be also provided as well as manuscripts prepared by the teachers

Teaching methods and learning activities

Theoretical classes , Laboratory classes. Discussion classes.

keywords

Health sciences > Medical sciences > Veterinary medicine > Animal immunology

Evaluation Type

Evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	100,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	79,00
Frequência das aulas	56,00
Total:	135,00

Eligibility for exams

Participation in a minimum of 3/4 of the laboratory classes

Calculation formula of final grade

Mark obtained in the final exam 

Special assessment (TE, DA, ...)

According to the specific rules approved by ICBAS

Classification improvement

According to the specific rules approved by ICBAS