Immunology
Keywords |
Classification |
Keyword |
OFICIAL |
Basic Sciences |
Instance: 2007/2008 - 2S
Cycles of Study/Courses
Acronym |
No. of Students |
Study Plan |
Curricular Years |
Credits UCN |
Credits ECTS |
Contact hours |
Total Time |
MIMV |
93 |
Plan 2007 to 2017 |
2 |
- |
5 |
64 |
135 |
Teaching language
Portuguese
Objectives
1. Acquisition of knowledge and skills on fundamental immunology, emphasizing the particular specificities of different domestic animals.
2. Acquisition of skills helpful for a better understanding of basic and advanced bibliographic information in the area of immunology.
3. Acquisition and development of rational mechanisms useful for the interpretation of immunological data and resolution of immunological problems.
4. Acquisition of skills for self-oriented study, including the correct usage of specific databases.
5. Improvement of communication skills regarding oral and written transmission of knowledge.
6. Acquisition of skills and knowledge on specific immunological diagnostic techniques.
7. Improvement of laboratory skills.
Program
1. Introduction to the immune system.
1.1. General introduction to the immune system. Pathogen-associated molecular patterns (PAMPs) and pattern recognition receptors (PRRs).
1.2. Primary and secondary lymphoid organs. Diffuse lymphoid tissue.
2. Cellular and mollecular components of the immune system and antigen recognition.
2.1. Hematopoietic development.
2.2. Functional and structural phenotypic characteristics of non-lymphoid immune cells.
2.3. Immunoglobulins. B-cell receptor (BCR).
2.4. Antigen-antibody reactions.
2.5. V(D)J recombination and generation of diversity in immunoglobulins and T-cell receptor (TCR).
2.5. TCR, Structure and function.
2.6. MHC. Antigen presentation.
3. Ontogeny and dinamics of lymphoid populations.
3.1. Ontogeny and activation of B-cells.
3.2. Activation of T-cells and B-T-cell cooperation.
3.3. Maturation of T and NK cells.
4. Effector Mechanisms.
4.1. Citokynes. Differentiation and function of T-cells. Role of dendritic cells.
4.2. Complement.
4.3. Lymphocyte recirculation, cell-adhesion molecules and inflammation.
4.4. Immune response during infection.
4.5. Immunity in body surfaces
4.5. Vaccines.
5. The immune system in physiological and pathologycal conditions.
5.1. Hypersensitivity reactions.
5.2. Blood groups in domestic animals.
5.3. Tolerance and autoimmunity.
5.4. Transplantation.
5.5. Immunodeficiencies.
6. Evolution of the immune system.
Laboratory and practical classes
1. Isolation of murine spleen mononuclear cells.
2. Assessment of a primary immune response.
3. B-cell response to a mitogen. Quantification of serum immunoglobilins by “Sandwich-ELISA”.
4. Thymus and Bone-marrow. Phenotyping of lymphoid precursors by flow cytometry.
5. Immunization.
6. Blood groups.
7. Presentation of scientific papers*
*several classes during the semester
Mandatory literature
Janis Kuby, Thomas J. Kindt, Barbara A. Osborne, and Richard A. Goldsby ; Immunology, W.H.Freeman & Co Ltd, 2006. ISBN: 0716767643
Abul K. Abbas , Andrew H. Lichtman, Shiv Pillai ; Cellular and Molecular Immunology, Saunders, 2007. ISBN: 1416031227
Ian Tizard; Veterinary Immunology, Saunders, 2008
Teaching methods and learning activities
Theoretical classes (including a few lectures by invited immunologists on particular subjects), Laboratory classes, presentation of scientific papers by the students.
keywords
Health sciences > Medical sciences > Veterinary medicine > Animal immunology
Evaluation Type
Distributed evaluation with final exam
Assessment Components
Description |
Type |
Time (hours) |
Weight (%) |
End date |
Subject Classes |
Participação presencial |
68,00 |
|
|
2 Partial Tests |
Exame |
4,00 |
|
|
Final Exam |
Exame |
2,00 |
|
|
Papers presentations |
Trabalho escrito |
2,00 |
|
|
|
Total: |
- |
0,00 |
|
Eligibility for exams
Participation in a minimum of 2/3 of the laboratory classes
Calculation formula of final grade
Sum of:
Mark on theoretical tests or exam (up to 16)
mark obtained on scientific papers presentations (up to 2,5)
Active participation on classes along the yeart (up to 1,5).
Examinations or Special Assignments
Oral paper presentations.
Special assessment (TE, DA, ...)
According to general law, and specific rules approved by ICBAS
Classification improvement
According to general law, and specific rules approved by ICBAS
Observations
Lecturing will not be based or folow a given textbook. The recomended bibliography should thus be considered as complementary material to that presented in the course classess