Thalamic volumetric abnormalities in type 1 diabetes mellitus and 'peripheral' neuropathy

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Novo, JL (Author) Other; Ruas, JJ (Author) Other; Ferreira, LM (Author) Other; Carvalho, Davide (Author) FMUP; Barbosa, M (Author) Other; Brandao, S (Author) Other; de Bastos Leite, AJ (Author) Other

Journal

Title: Scientific Reports

Vol. 12

ISSN: 2045-2322

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00W-ZR3

DOI: 10.1038/s41598-022-16699-x

Abstract (EN): We hypothesized that thalamic volumes of patients with type 1 diabetes mellitus (DM) and nonpainful diabetic peripheral neuropathy (DPN) would be reduced relative to thalamic volumes of patients with type 1 DM and painful DPN. We calculated the standardized thalamic volumetric difference between these groups in a pilot sample to obtain a statistical power of 80% at a 5% significance level. Hence, we measured thalamic volumes from 15 patients with nonpainful DPN (10 women, mean age = 49 years, standard deviation [SD] = 11.5) and from 13 patients with painful DPN (8 women, mean age = 43 years, SD = 12.5) by using a manual segmentation approach. A volumetric difference of approximately 15% was found between the nonpainful (mean = 5072 mm(3), SD = 528.1) and painful (mean = 5976 mm(3), SD = 643.1) DPN groups (P < 0.001). Curiously, a volumetric difference between the left (mean = 5198 mm(3), SD = 495.0) and the right (mean = 4946 mm(3), SD = 590.6) thalamus was also found in patients with nonpainful DPN (P < 0.01), but not in patients with painful DPN (P = 0.97). Patients with nonpainful DPN have lower thalamic volumes than those with painful DPN, especially in the right thalamus.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7