Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects

• Type: Chapter or Part of a Book
• Date: 2022

Authors

Luciana Gomes (Author) FEUP; Rita Teixeira dos Santos (Author) FEUP; Maria João Romeu (Author) FEUP; Filipe Mergulhão (Author) FEUP

Book

Title: Urinary Stents: Current State and Future Perspectives

Pages: 225-243

ISBN: 978-303104484-7; 978-303104483-0

Indexing

Scopus - 0 Citations

Associated Projects

2SMART - 2SMART - engineered Smart materials for Smart citizens

NanoCAT - NanoCAT - Utilização de nanotubos de carbono modificados para combater infecções em catéteres urinários e stents

LEPABE - Financiamento Plurianual 2020-2023 da Unidade de I&D LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

ALiCE - ALiCE - Laboratório Associado em Engenharia Química

Other information

Authenticus ID: P-00Y-QJS

DOI: 10.1007/978-3-031-04484-7_19

Abstract (EN): <jats:title>Abstract</jats:title><jats:p>The effectiveness of biomedical surfaces may be highly affected by the hydrodynamic condition. Surfaces releasing antimicrobial substances when exposed to flow may exhibit shorter lifetimes than at static conditions. Likewise, depending on the fluid flow surrounding the surface, contact-killing surfaces that are adhesive for bacterial cells may be covered by bacterial debris, which decreases their antimicrobial activity. To evaluate the anti-adhesive and antimicrobial performance of novel biomedical materials, a number of flow devices have been designed to recreate <jats:italic>in vivo</jats:italic> flow conditions. Shear stress and flow rate can be accurately controlled and varied in these <jats:italic>in vitro</jats:italic> flow systems, which requires prior knowledge of the flow dynamics inside the platform. After limiting their operational range, modified Robbins devices, flow chambers and microfluidic devices are suggested as experimental setups to mimic the flow behavior in urinary catheters and stents.</jats:p>

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18