Ibuprofen Potentiates the In Vivo Antifungal Activity of Fluconazole against Candida albicans Murine Infection

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Sofia Costa de Oliveira (Author) FMUP; miranda, im (Author) FMUP; Silva Dias, A (Author) Other; Silva, AP (Author) Other; rodrigues, ag (Author) FMUP; pina-vaz, c (Author) FMUP

Journal

Title: Antimicrobial Agents and Chemotherapy

Vol. 59

Pages: 4289-4292

ISSN: 0066-4804

Publisher: American Society for Microbiology

Indexing

ISI Web of Knowledge - 28 Citations

Scopus - 31 Citations

Other information

Authenticus ID: P-00G-D8G

DOI: 10.1128/aac.05056-14

Abstract (EN): Candida albicans is the most prevalent cause of fungemia worldwide. Its ability to develop resistance in patients receiving azole antifungal therapy is well documented. In a murine model of systemic infection, we show that ibuprofen potentiates fluconazole antifungal activity against a fluconazole-resistant strain, drastically reducing the fungal burden and morbidity. The therapeutic combination of fluconazole with ibuprofen may constitute a new approach for the management of antifungal therapeutics to reverse the resistance conferred by efflux pump overexpression.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4