Apresentação Pessoal

Holds a graduation (2007) and a MSc degree (2008) in Biochemistry (FCUP and ICBAS-UP, Portugal), and a Ph.D. in Biomedical Sciences (2014) by the University of Porto (ICBAS-UP). Worked as a young researcher at Arrhenius Institute, Stockholm University, and as a Cellular and Molecular Scientist in a Biopharmaceutical company (Phyzat Biopharmaceuticals, Lda); JBNM is currently working as an Assistant Professor of Pharmacology and Neurosciences at the Department of Imuno-Physiology and Pharmacology (ICBAS-UP).

JBNM has over 15 years of experience in pre-clinical R&D projects in the biomedical field and has been involved in 15 different projects, both as a researcher and Principal Investigator. His research is focused on cell ageing and on new pharmacological targets in pluripotent/immunomodulatory mesenchymal stem cells (MSCs) for treating bone and cartilage disorders. JBNM holds a strong scientific background and expertise on MSC and lentiviral vector-based silencing techniques (RNAi) and has proposed new and innovative cell-rejuvenating methods using purinergic receptor modulating drugs, with significant clinical application. JBNM has post-graduation expertise in Live cell Imaging Techniques and Imaging Processing applied to life sciences for development of innovative therapeutic solutions in collaboration with national/international research teams and hospitals.

JBNM actively cooperates in projects designed to understand the neuromuscular transmission in autoimmune disorders, such as Myasthenia Gravis. He also studies the biological activity profile of snake venom components in the context of neuromuscular transmission, namely bothropstoxin-I from Bothrops jararacussu and crotoxin from Crotalus durissus terrificus. He is a member of the scientific committee of the Doctoral Programme in Neuroscience since 2019. JBNM possesses a growing experience as a student’s supervisor (PhD and Master degree). JBNM has been invited to be part of several evaluation committees (EC), to elaborate seminars and workshops in the context of RNAi and cell senescence, and to participate as a reviewer for several international peer reviewed journals. 

Recent projects:

JBNM (PI): New insights of the purinome in predicting bone healing by mesenchymal stromal cells in osteoporotic patients (2022-2024). Fundação para a Ciência e Tecnologia: Projetos de investigação de carácter exploratório (PeX), EXPL/MED-FAR/1065/2021.

JBNM (Researcher): Regeneration of the ageing human bone by purinome-activated mesenchymal stem cells – pre-clinical studies (2018-2021). Portugal2020: Projetos de Investigação Científica e Desenvolvimento Tecnológico (IC&DT): AAC nº 02/SAICT/2017 - Candidatura nº 029398. FCT, PTDC/MEDFAR/ 29398/2017, Fundo Europeu de Desenvolvimento Regional (FEDER, European Union, POCI-01-0145-FEDER-029398).

JBNM (Researcher): Purinome-rejuvenated autologous STEM cells against COVID-19. Who’s gonna win the ageing battle? (2020-2021). FCT: RESEARCH 4 COVID; – ID: 613459351; FCT nº 402.

Most relevant international scientific papers: 

1. Bessa-Andrês C, Pinto-Cardoso R, Tarasova K, Pereira-Gonçalves AL, Gaio-Ferreira-Castro JM, Carvalho LS, Costa MA, Ferreirinha F, Canadas-Sousa A, Marinhas J, Freitas R, Lemos R, Vilaça A, Oliveira A, Correia-de-Sá P & Noronha-Matos JB. (2024). Mechanical stimulation-induced purinome priming fosters osteogenic differentiation and osteointegration of mesenchymal stem cells from the bone marrow of postmenopausal women. StemCell Research & Therapy 15(1):168. PMID: 38886849. https://doi.org/10.1186/s13287-024-03775-4.

 

2. Pinto-Cardoso R, Bessa-Andrês C, Correia-de-Sá P, Noronha-Matos JB. (2023). Could hypoxia rehabilitate the osteochondral diseased interface? Lessons from the interplay of hypoxia and purinergic signals elsewhere. Biochemical Pharmacology 214 (2023) 115646. PMID: 37321413. https://doi.org/10.1016/j.bcp.2023.115646.

 

3. Noronha-Matos JB, Pinto-Cardoso R, Bessa-Andrês C, Magalhães-Cardoso MT, Ferreirinha F, Costa MA, Marinhas J, Freitas R, Lemos R, Vilaça A, Oliveira A, Pelletier J, Sévigny J, Correia-de-Sá P. (2023). Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stemcell bone progenitors. Stem Cell Research & Therapy 14, 97 (2023). PMID: 37076930. https://doi.org/10.1186/s13287-023-03315-6.

 

4. Sousa-Soares C, Noronha-Matos JB, Correia-de-Sá P. (2023). Purinergic Tuning of the tripartite neuromuscular synapse. Molecular Neurobiology, 60, 4084-4104. PMID:  doi: 10.1007/s12035-023-03317-8.

 

5. Oliveira M, Mathias LS, Sibio MT, Noronha-Matos JB, Costa MA, Nogueira CR, Correia-de-Sá P. (2020). Pitfalls and challenges of the purinergic signaling cascade in obesity. Biochemical Pharmacology, 182, 114214. PMID: doi: 10.1016/j.bcp.2020.114214.

 

6. Noronha-Matos JB, Oliveira L, Peixoto AR, Almeida L, Castellão-Santana L, Ambiel CR, Alves-do-Prado W, Correia-de-Sá P. (2020). Nicotinic α7 receptor‐induced adenosine release from perisynaptic Schwann cells controls acetylcholine spillover from motor endplates. Journal of Neurochemistry, 154, 263-283. PMID: 32011735. doi: 1111/jnc.14975.

 

7. Pinto-Cardoso R, Pereira-Costa F, Faria JP, Bandarrinha P, Andrês-Bessa C, Correia-de-Sá P, Noronha-Matos JB. (2020). Adenosinergic signalling in chondrogenesis and cartilage homeostasis: friend or foe? Biochemical Pharmacology, 174, 113784. PMID: doi: 10.1016/j.bcp.2019.113784. 

 

8. Castellão-Santana LM, Yumi Abiko P, Ambiel CR, Peixoto AR, Noronha-Matos JB, Correia-de-Sá P, Alves-do-Prado W. (2019). Tetanic facilitation of neuromuscular transmission by adenosine A_2A and muscarinic M₁ receptors is dependent on the uptake of choline via high-affinity transporters. Pharmacology, 103, 38-49. PMID:30380560. doi: 10.1159/000494058. 

 

9. Cavalcante WLG, Noronha-Matos JB, Timóteo MA, de Mattos Fontes MR, Gallacci M and Correia-de-Sá P. (2017). Neuromuscular paralysis by the basic phospholipase A₂ subunit of crotoxin from Crotalus durissus terrificus snake venom needs its acid chaperone to concurrently inhibit acetylcholine release and produce muscle blockage. Toxicology and Applied Pharmacology, 334, 8-17.doi: 1016/j.taap.2017.08.021. 

 

10. Noronha-Matos JB and Correia-de-Sá P. (2016). Mesenchymal stem cells: Targeting the “Purinome” to promote osteogenic differentiation and bone repair. Journal of Cellular Physiology, 231, 1852-1861. PMID: 26754327. doi: 1002/jcp.25303.

 

11. Oliveira L, Costa AC, Noronha-Matos JB, Silva I, Cavalcante WLG, Corrado AP, Dal Belo CA, Ambiel CR, Alves-do-Prado W and Correia-de-Sá P. (2015). Amplification of neuromuscular transmission by methylprednisolone involves activation of presynaptic facilitatory adenosine A_2A receptors and redistribution of synaptic vesicles. Neuropharmacology, 89, 64-76. PMID: 25220030. doi: 10.1016/j.neuropharm.2014.09.004. 

 

12. Noronha-Matos JB, Coimbra J, Sá-e-Sousa A, Rocha R, Marinhas J, Freitas R, Gomes-Guerra S, Ferreirinha F, Costa MA and Correia-de-Sá (2014). P2X7-induced zeiosis promotes osteogenic differentiation and mineralization of postmenopausal bone marrow derived mesenchymal stem cells. Faseb Journal, 28, 5208-5222. PMID: 25169056. doi:10.1096/fj.14-257923.

 

13. Timóteo MA, Carneiro C, Silva I, Noronha-Matos JB, Ferreirinha F, Silva-Ramos F, Correia-de-Sá P. (2013). ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors. Biochemical Pharmacology, 87, 371-379. PMID: 24269631. doi: 10.1016/j.bcp.2013.11.007.

 

14. Fernandes C, Oliveira L, Tiritan MA, Leitao L, Pozzi A, Noronha-Matos JB, Correia-de-Sá P, Pinto MM. (2012). Synthesis of new chiral xanthone derivatives acting as nerve conduction blockers in the rat sciatic nerve. European Journal of Medicinal Chemistry, 55, 1-11. PMID: 22819594. doi: 10.1016/j.ejmech.2012.06.049.

 

15. Correia-de-Sá P, Noronha-Matos JB, Timóteo MA, Ferreirinha F, Marques P, Soares AM, Carvalho C, Cavalcante WLG, Gallacci M. (2012). Bothropstoxin-I reduces evoked acetylcholine release from rat motor nerve terminals: Radiochemical and real-time video microscopy studies. Toxicon, 61, 16-25. PMID: 23142504. doi: 10.1016/j.toxicon.2012.10.014.

 

16. Noronha-Matos JB, Costa MA, Magalhães-Cardoso T, Ferreirinha F, Freitas R, Neves JM, Sévigny J and Correia-de-Sá (2012). Role of ecto-NTPDases on UDP-sensitive P2Y₆ receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal woman. Journal of Cellular Physiology, 227, 2694-2709. PMID: 21898410. doi: 10.1002/jcp.23014.

 

17. Noronha-Matos JB, Morais T, Trigo D, Timóteo MA, Oliveira L and Correia-de-Sá P. (2011). Tetanic failure due to decreased endogenous adenosine A_2A tonus operating neuronal Ca_v1 (L-type) influx in Myasthenia gravis. Journal of Neurochemistry, 117, 797-811. PMID: 21323926. doi: 10.1111/j.1471-4159.2011.07216.x.

 

18. Blom KG, Qazi MR, Noronha-Matos JB, Nelson BD, DePierre JW, Abedi-Valugerdi M. (2009). Isolation of murine intrahepatic immune cells employing a modified procedure for mechanical disruption and functional characterization of the B, T and natural killer T cells obtained. Clinical and Experimental Immunology, 155, 320-329. PMID: doi: 10.1111/j.1365-2249.2008.03815.x.

Áreas de Interesse

1. Health sciences > Medical sciences > Medicine
2. Health sciences > Neuroscience > Neurobiology
3. Health sciences > Neuroscience > Neurochemistry