Apresentação Pessoal

JBNM holds a B.Sc. (2007) and an M.Sc. in Biochemistry (2008) from the Faculty of Sciences (FCUP) and the Institute of Biomedical Sciences Abel Salazar (ICBAS) at the University of Porto, Portugal. He earned his Ph.D. in Biomedical Sciences (2014) from the University of Porto (ICBAS-UP). He worked as a young researcher at the Arrhenius Institute of Stockholm University and gained experience in the biopharmaceutical industry. Currently, JBNM serves as an Assistant Professor in the Department of Immunophysiology and Pharmacology at ICBAS-UP.

JBNM has over 18 years of experience in biomedical R&D projects, having participated in more than 16 research projects as either principal investigator or collaborator. His research focuses on identifying novel pharmacological targets in multipotent/immunomodulatory mesenchymal stem cells (MSCs) for the treatment of bone and cartilage disorders. With a view to clinical translation, he has proposed innovative strategies for cellular rejuvenation, employing gene silencing techniques (RNAi), selective pharmacological agents, and in vitro mechanical stimulation, targeting the “purinome.”

He also holds postgraduate training in Live Cell Imaging and Image Processing techniques applied to life sciences. He actively collaborates with international research groups and national hospitals.

In collaboration with the Laboratory of Pharmacology and Neurobiology, JBNM has contributed to projects investigating neuromuscular transmission in autoimmune disorders, such as Myasthenia gravis.

Since 2019, he has been a member of the Scientific Committee of the Doctoral Program in Neurosciences. JBNM has extensive experience supervising Ph.D. candidates, Master’s students, and postdoctoral researchers. He has been invited to serve on several national and international project evaluation panels, to deliver seminars on RNAi and cellular senescence, and to act as a reviewer for various international journals.

Recent projects:

JBNM (PI): New insights of the purinome in predicting bone healing by mesenchymal stromal cells in osteoporotic patients (2022-2024). Fundação para a Ciência e Tecnologia: Projetos de investigação de carácter exploratório (PeX), EXPL/MED-FAR/1065/2021.

JBNM (Researcher): Regeneration of the ageing human bone by purinome-activated mesenchymal stem cells – pre-clinical studies (2018-2021). Portugal2020: Projetos de Investigação Científica e Desenvolvimento Tecnológico (IC&DT): AAC nº 02/SAICT/2017 - Candidatura nº 029398. FCT, PTDC/MEDFAR/ 29398/2017, Fundo Europeu de Desenvolvimento Regional (FEDER, European Union, POCI-01-0145-FEDER-029398).

JBNM (Researcher): Purinome-rejuvenated autologous STEM cells against COVID-19. Who’s gonna win the ageing battle? (2020-2021). FCT: RESEARCH 4 COVID; – ID: 613459351; FCT nº 402.

Most relevant international scientific papers: 

1. Bessa-Andrês C, Pinto-Cardoso R, Costa MA, Ferreirinha F, Marinhas J, Freitas R, Lemos R, Catelas D, Vilaça A, Oliveira A, Correia-de-Sá P* & Noronha-Matos JB* (2025). Silencing P2Y₁₂and P2Y₁₃ receptors rehabilitates ADP-induced P2Y₁-mediated deficits of osteogenesis in post-menopausal mesenchymal stromal cells. Cell Communication and Signaling 2025; 23: 353. PMID: 40713640. doi: 10.1186/s12964-025-02355-0.

 

2. Pinto-CardosoR, Bessa-AndrêsC, Pereira-CostaF, Neiva R, Martins-FerreiraR, LealB, Catelas DN, Vilaça A, Oliveira A, Pelletier J, Sévigny J, Noronha-Matos JB & Correia-de-Sá P (2025). HIF‐1α overexpression hampers chondrogenic stem cells differentiation by adenosine A_2A /A_2B. ACS Pharmacology & Translational Science 8(7):2075-2092. PMID: 40672664. doi: 10.1021/acsptsci.5c00190. 

 

3. Noronha-Matos JB*, Sousa-Soares C, Correia-de-Sá P* (2024). Differential participation of CaMKII/ROCK and NOS pathways in the cholinergic inhibitory drive operated by nicotinic α7 receptors in perisynaptic Schwann cells. Biochemical Pharmacology 231 (2025) 116649.  PMID: 39581530. doi: 10.1016/j.bcp.2024.116649.

 

4. Bessa-Andrês C, Pinto-Cardoso R, Tarasova K, Pereira-Gonçalves AL, Gaio-Ferreira-Castro JM, Carvalho LS, Costa MA, Ferreirinha F, Canadas-Sousa A, Marinhas J, Freitas R, Lemos R, Vilaça A, Oliveira A, Correia-de-Sá P* & Noronha-Matos JB*. (2024). Mechanical stimulation-induced purinome priming fosters osteogenic differentiation and osteointegration of mesenchymal stem cells from the bone marrow of postmenopausal women. Stem Cell Research & Therapy 2024; 15(1):168. PMID: 38886849. https://doi.org/10.1186/s13287-024-03775-4.

 

5. Pinto-Cardoso R, Bessa-Andrês C, Correia-de-Sá P*, Noronha-Matos JB*. (2023). Could hypoxia rehabilitate the osteochondral diseased interface? Lessons from the interplay of hypoxia and purinergic signals elsewhere. Biochemical Pharmacology 214 (2023) 115646. PMID: 37321413. https://doi.org/10.1016/j.bcp.2023.115646

 

6. Noronha-Matos JB*, Pinto-Cardoso R, Bessa-Andrês C, Magalhães-Cardoso MT, Ferreirinha F, Costa MA, Marinhas J, Freitas R, Lemos R, Vilaça A, Oliveira A, Pelletier J, Sévigny J, Correia-de-Sá P*. (2023). Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stemcell bone progenitors. Stem Cell Research & Therapy 2023; 14(1): 97. PMID: 37076930. https://doi.org/10.1186/s13287-023-03315-6

 

7. Sousa-Soares C, Noronha-Matos JB*, Correia-de-Sá P*. (2023). Purinergic Tuning of the tripartite neuromuscular synapse. Molecular Neurobiology, 60, 4084-4104. PMID:  doi: 10.1007/s12035-023-03317-8

 

8. Oliveira M, Mathias LS, Sibio MT, Noronha-Matos JB, Costa MA, Nogueira CR, Correia-de-Sá P. (2020). Pitfalls and challenges of the purinergic signaling cascade in obesity. Biochemical Pharmacology, 182, 114214. PMID: doi: 10.1016/j.bcp.2020.114214

 

9. Noronha-Matos JB, Oliveira L, Peixoto AR, Almeida L, Castellão-Santana L, Ambiel CR, Alves-do-Prado W, Correia-de-Sá P. (2020). Nicotinic α7 receptor‐induced adenosine release from perisynaptic Schwann cells controls acetylcholine spillover from motor endplates. Journal of Neurochemistry, 154, 263-283. PMID: 32011735. doi: 1111/jnc.14975.

 

10. Pinto-Cardoso R, Pereira-Costa F, Faria JP, Bandarrinha P, Andrês-Bessa C, Correia-de-Sá P*, Noronha-Matos JB*. (2020). Adenosinergic signalling in chondrogenesis and cartilage homeostasis: friend or foe? Biochemical Pharmacology, 174, 113784. doi: 10.1016/j.bcp.2019.113784. 

 

11. Castellão-Santana LM, Yumi Abiko P, Ambiel CR, Peixoto AR, Noronha-Matos JB, Correia-de-Sá P, Alves-do-Prado W. (2019). Tetanic facilitation of neuromuscular transmission by adenosine A_2A and muscarinic M₁ receptors is dependent on the uptake of choline via high-affinity transporters. Pharmacology, 103, 38-49. PMID:30380560. doi: 10.1159/000494058.

 

12. Cavalcante WLG¹, Noronha-Matos JB¹, Timóteo MA, de Mattos Fontes MR, Gallacci M and Correia-de-Sá P. (2017). Neuromuscular paralysis by the basic phospholipase A₂ subunit of crotoxin from Crotalus durissus terrificus snake venom needs its acid chaperone to concurrently inhibit acetylcholine release and produce muscle blockage. Toxicology and Applied Pharmacology, 334, 8-17.doi: 1016/j.taap.2017.08.021.

 

13. Noronha-Matos JB and Correia-de-Sá P. (2016). Mesenchymal stem cells: Targeting the “Purinome” to promote osteogenic differentiation and bone repair. Journal of Cellular Physiology, 231, 1852-1861. PMID: 26754327. doi: 1002/jcp.25303.

 

14. Oliveira L, Costa AC, Noronha-Matos JB, Silva I, Cavalcante WLG, Corrado AP, Dal Belo CA, Ambiel CR, Alves-do-Prado W and Correia-de-Sá P. (2015). Amplification of neuromuscular transmission by methylprednisolone involves activation of presynaptic facilitatory adenosine A_2A receptors and redistribution of synaptic vesicles. Neuropharmacology, 89, 64-76. PMID: 25220030. doi: 10.1016/j.neuropharm.2014.09.004.

 

15. Noronha-Matos JB, Coimbra J, Sá-e-Sousa A, Rocha R, Marinhas J, Freitas R, Gomes-Guerra S, Ferreirinha F, Costa MA and Correia-de-Sá (2014). P2X7-induced zeiosis promotes osteogenic differentiation and mineralization of postmenopausal bone marrow derived mesenchymal stem cells. Faseb Journal, 28, 5208-5222. PMID: 25169056. doi:10.1096/fj.14-257923

 

16. Timóteo MA, Carneiro C, Silva I, Noronha-Matos JB, Ferreirinha F, Silva-Ramos F, Correia-de-Sá P. (2013). ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors. Biochemical Pharmacology, 87, 371-379. PMID: 24269631. doi: 10.1016/j.bcp.2013.11.007

 

17. Fernandes C, Oliveira L, Tiritan MA, Leitao L, Pozzi A, Noronha-Matos JB, Correia-de-Sá P, Pinto MM. (2012). Synthesis of new chiral xanthone derivatives acting as nerve conduction blockers in the rat sciatic nerve. European Journal of Medicinal Chemistry, 55, 1-11. PMID: 22819594. doi: 10.1016/j.ejmech.2012.06.049

 

18. Correia-de-Sá P, Noronha-Matos JB, Timóteo MA, Ferreirinha F, Marques P, Soares AM, Carvalho C, Cavalcante WLG, Gallacci M. (2012). Bothropstoxin-I reduces evoked acetylcholine release from rat motor nerve terminals: Radiochemical and real-time video microscopy studies. Toxicon, 61, 16-25. PMID: 23142504. doi: 10.1016/j.toxicon.2012.10.014

 

19. Noronha-Matos JB, Costa MA, Magalhães-Cardoso T, Ferreirinha F, Freitas R, Neves JM, Sévigny J and Correia-de-Sá (2012). Role of ecto-NTPDases on UDP-sensitive P2Y₆ receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal woman. Journal of Cellular Physiology, 227, 2694-2709. PMID: 21898410. doi: 10.1002/jcp.23014.

 

20. Noronha-Matos JB, Morais T, Trigo D, Timóteo MA, Oliveira L and Correia-de-Sá P. (2011). Tetanic failure due to decreased endogenous adenosine A_2A tonus operating neuronal Ca_v1 (L-type) influx in Myasthenia gravis. Journal of Neurochemistry, 117, 797-811. PMID: 21323926. doi: 10.1111/j.1471-4159.2011.07216.x

 

21. Blom KG, Qazi MR, Noronha-Matos JB, Nelson BD, DePierre JW, Abedi-Valugerdi M. (2009). Isolation of murine intrahepatic immune cells employing a modified procedure for mechanical disruption and functional characterization of the B, T and natural killer T cells obtained. Clinical and Experimental Immunology, 155, 320-329. PMID: doi: 10.1111/j.1365-2249.2008.03815.x

Áreas de Interesse

1. Health sciences > Medical sciences > Medicine
2. Health sciences > Neuroscience > Neurobiology
3. Health sciences > Neuroscience > Neurochemistry
4. Technological sciences > Engineering > Biomedical enginnering