Name: PAULO JORGE DA SILVA CORREIA DE SÁ

Full Professor of Pharmacology and Neurosciences, MD, PhD

Head of Laboratory of Pharmacology and Neurobiology

Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto

R. Jorge Viterbo Ferreira, 228, 4050-313 Porto, PORTUGAL

Tel: 351 22 0428 212, Fax: 351 22 0428 090, E-mail: farmacol@icbas.up.pt

1)     Education

2)     Position and Honours.

Full Professor of Pharmacology and Neurosciences, ICBAS-UP (October, 2007); Tenure faculty position (November 2009).

Associate Professor of Pharmacology and Therapeutics, ICBAS/UP (April, 2004 – September, 2007).

Assistant Professor of Pharmacology and Therapeutics, ICBAS/UP (October, 1997 – March, 2004).

Young Research Fellow at the Laboratory of Pharmacology, ICBAS/UP (September, 1986 – September, 1989).

Head of the Department of Immuno-Physiology and Pharmacology, ICBAS/UP (January, 2000 - 2019).

Head of the Laboratory of Pharmacology and Neurobiology, ICBAS/UP (April, 1999 - ).

Scientific Coordinator for the Medicine Curriculum, ICBAS/UP (2000-2001, 2004-2005).

Coordinator of the Pharmacology and Therapeutics Curriculum (Courses of Medicine and Veterinary Medicine), ICBAS/UP (April, 1999 - ).

Coordinator Professor of Anatomy, Physiology and Neurosciences, Superior School of Nurses of D. Ana Guedes (Porto) (October, 1995 – September, 1999).

President of the Portuguese Society for Pharmacology (February 2013 - )

President of the Unit for Multidisciplinary Investigation in Biomedicine (UMIB), FCT - Programa de Financiamento Plurianual de Unidades de I&D (January, 2004-14 ).

Vice-President of the Scientific Council, ICBAS/UP (January, 2002 – December, 2003).

Member of the Council for Financial Activities of the Portuguese Society for Neurosciences (SPN) (July, 2003 - ).

Member of the Portuguese Pharmacopea Commission, INFARMED (December, 2000 - ).

3)     Publications (10 more relevant hints).

3.a) P. Correia-de-Sá, A.M. Sebastião & J.A. Ribeiro. Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the rat. Br. J. Pharmacol. (1991), 103, 1614 -1620. Citado WOS por 117.

3.b) R.A. Cunha, P. Correia-de-Sá, A.M. Sebastião & J.A. Ribeiro. Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides. Br. J. Pharmacol. (1996), 119, 253-260. Citado WOS por 114.

3.c) P. Correia-de-Sá, M.A. Timóteo & J.A. Ribeiro. Presynaptic A1-inhibitory / A2A-facilitatory adenosine receptor activation balance depends on motor nerve stimulation paradigm at the rat hemidiaphragm. J. Neurophysiol. (1996), 76 (6), 3910-3919. Citado WOS por 103.

3.d) P. Correia-de-Sá & J.A. Ribeiro. Tonic A2a-adenosine receptor activation modulates nicotinic autoreceptor function at the rat neuromuscular junction. Eur. J. Pharmacol. (1994), 271, 349-355. Citado WOS por 61.

3.e) M.A. Costa, A. Barbosa, E. Neto, A. Sá-e-Sousa, R. Freitas, J.M. Neves, T. Magalhães-Cardoso, F. Ferreirinha & P. Correia-de-Sá. On the role of subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow stromal cells. J. Cell. Physiol. (2011) 226, 1353-1366. Citado WOS por 59.

3.f)  M. Faria, L. Oliveira, M.A. Timóteo, M.G. Lobo & P. Correia-de-Sá. Blockade of neuronal facilitatory nicotinic receptors containing alpha3beta2 subunits contribute to tetanic fade in the rat isolated diaphragm. Synapse (2003), 49, 77-88. Citado WOS por 62.

3.g) J.A. Ribeiro, R.A. Cunha, P. Correia-de-Sá & A.M. Sebastião. Purinergic regulation of acetylcholine release. Prog. Brain Res. - Cholinergic Mechanisms: From Molecular Biology to Clinical Significance (Eds. J. Klein & K. Löffelholz) (1996), 109 (23), 231-241. Citado WOS por 53.

3.h) A.R. Pinheiro, D. Paramos-de-Carvalho, M. Certal, M.A. Costa, A.C. Costa, M.T. Magalhães-Cardoso, F. Ferreirinha, J. Sévigny & P. Correia-de-Sá. Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation. J. Biol. Chem. (2013) 288, 27571–27583. Citado WOS por 47.

3.i) A. Charrua, C. Reguenga C, J.M. Cordeiro, P. Correia-de-Sá, C. Paule, I. Nagy, F. Cruz & A. Avelino. Functional transient receptor potential vanilloid 1 is expressed in human urothelial cells. J. Urol. (2009) 182, 2944-2950. Citado WOS por 45.

3.j) M.A. Timóteo, I. Carneiro, I. Silva, J.B. Noronha-Matos, F. Ferreirinha, M. Silva-Ramos & P. Correia-de-Sá. ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors. Biochem Pharmacol. (2014) 87, 371-379. Citado WOS por 43.

4)     Scientific Research Projects (last 3 years).

4.a) P. Soares da Silva, P. Correia-de-Sá et al. (2016-17) – Scientific Executive Committee. Center for Drug Discovery and Innovative Medicines – University of Porto (MedInUP). Programa de Recuperação de Unidades de I&D – 2016. Subsidiado pela FCT, Projeto UID/BIM/4308/2016 (102,300¤).

4.b) M. Mattos-Fontes, P. Correia-de-Sá et al. (2016-18). Structural and functional studies aiming to understand the role of snake venoms toxins and how to inhibit their biological activity Subsidiado pela FAPESP, Projecto de Auxílio à Pesquisa – Regular, Projecto 2015/17286-0 (211,859.72R$).

4.c) D.G. Sousa, M. Silva-Ramos, D. Reis, I. Silva, T. Magalhães-Cardoso & P. Correia-de-Sá (2016-17). Impacto do tadalafil na oxigenação e no tónus purinérgico da bexiga em doentes com obstrução infravesical por hiperplasia benigna da próstata (HBP). Bolsa de Investigação Associação Portuguesa de Urologia / Jaba Recordati Urologia 2016 (8,000 ¤).

4.d) M. Silva-Ramos, I. Silva & P. Correia-de-Sá (2018). OBDOM – Office-based bladder outlet obstruction marker. BIP Proof - Business Ignition Programme 2018 promovido pela U.Norte Inova e financiado pelo Norte2020, Portugal 2020 e União Europeia tendo como parceiros a Universidade do Porto, a Universidade do Minho, a Universidade de Trás-os-Montes e Alto Doutor e a TecMinho (20,000 ¤).

4.e) P. Correia-de-Sá et al. (2018-21). BONE-PURI(NO)AGEING - Regeneration of the ageing human bone by purinome-activated mesenchymal stem cells – pre-clinical studies. Subsidiado pela FCT/P2020, Projecto AAC nº 02/SAICT/2017 (Projetos de IC&DT), Candidatura POCI nº 029398, apoiado pelo FEDER e OE (223,717.50 ¤).

4.f)  D. Cunha-Reis & P. Correia-de-Sá et al. (2018-21). EPIRaft - Contribution of neuronal membrane and lipid raft remodelling to the pathophysiology of mesial temporal lobe epilepsy (MTLE): insight into the beneficial effects of the ketogenic diet therapy. Subsidiado pela FCT/P2020, Projecto AAC nº 02/SAICT/2017 (Projetos de IC&DT), referência LISBOA-01-0145-FEDER-028311, apoiado pelo FEDER e OE (236,512.18 ¤).

4.g) M.J. Diógenes & P. Correia-de-Sá et al. (2018-21). AdoRett - Adenosine levels reestablishment: new approach for the treatment of Rett Syndrome. Subsidiado pela FCT/P2020, Projecto AAC nº 02/SAICT/2017 (Projetos de IC&DT), referência LISBOA-01-0145-FEDER-031929, apoiado pelo FEDER e OE (239,791.35 ¤).

4.h) P. Osswald, F. Ambrósio & P. Correia-de-Sá (2018-20). SIRNAGLAU - Novel siRNA therapies against glaucoma. Colaboração: Phyzat Biopharmaceuticals, Lda. (empresa), CIBB - Universidade de Coimbra, MedInUP / ICBAS – Universidade do Porto. Financiado pela Agência de Inovação / Portugal 2020 / União Europeia, Sistema de Incentivos à Investigação e Desenvolvimento Tecnológico (SI I&DT), Aviso Nº 31/SI/2017, Projetos em Co-Promoção (470,255.85 ¤ / 172,451.94 ¤ / 134,192.07 ¤).

4.i) P. Soares da Silva, P. Correia-de-Sá et al. (2019) – Responsável Institucional. Center for Drug Discovery and Innovative Medicines – University of Porto (MedInUP). Financiamento de Unidades de I&D – 2019. Subsidiado pela FCT, Projeto UID/BIM/4308/2019 (51,150.00¤).

4.j) P. Correia-de-Sá (2020-21). Unravelling the cellular and molecular cardiopulmonary benefits of DBH inhibition in animals with pulmonary arterial hypertension. Colaboração: BIAL – PORTELA & Cª., S.A., e Lab Farmacologia e Neurobiologia / MedInUP, ICBAS - Universidade do Porto. Contrato de prestação de serviços de investigação nº PCS/BIAL/001/2019 - 160,000.00 ¤).

4.k) P. Soares da Silva, P. Correia-de-Sá et al. (2020-23) – Responsável Institucional. Center for Drug Discovery and Innovative Medicines – University of Porto (MedInUP). Fianciamento Plurianual de Unidades de I&D – 2020-23. Contrato-Programa FCT, Projeto UIDB/04308/2020 (Base 157,480.00¤) e UIDP/04308/2020 (Programático 276,000.00¤).

5)     PhD Students and PostDocs (last 3 years).

5.a) PhD Student - Miguel António Costa de Araújo da Silva Ramos (2009-2017). Role of endogenous purines (ATP and adenosine) in patients with lower urinary tract dysfunction. PhD Biomedical Sciences (ICBAS-UP).

5.b) PhD Student - Isabel Sofia Dias da Silva (2013-2018). Targeting the purinome to control hyperactivity of the human urinary bladder. PhD Biomedical Sciences (ICBAS-UP). PhD Studentship from FCT (SFRH/BD/88855/2012).

5.c) PhD Student (ongoing) - Bruno Miguel Martins Bragança (2015-). Purinergic signaling on cardioprotection afforded by caloric restriction. PhD Biomedical Sciences (ICBAS-UP). PhD Studentship from FCT (SFRH/BD/104114/2014).

5.d) PhD Student (ongoing) - Carina Talice Stube Herman de Sousa (2016-). Fibroblasts as mechano-sensory signaling intermediates between epithelia and primary afferent neurons: The “purinome” as a pharmacological target. PhD Experimental and Clinical Pharmacology and Toxicology (PDFTEC). PhD Studentship (PDFTEC), NORTE-08-5369-FSE-000011, Application NORTE-69-2015-15 (Advanced Formation – “Programas Doutorais”), cofunded by FSE – Fundo Social Europeu - NORTE2020 – Programa Operacional Regional do Norte.

5.e) PhD Student (ongoing) - Rui Miguel Pinto Cardoso (2018-). Recovery of aged cartilage by purinome-primed bone-marrow- and cartilage-derived stem cells PhD Biomedical Sciences (ICBAS-UP). PhD Studentship from FCT (SFRH/BD/135942/2018).

5.f)  PhD Student (ongoing) - Catarina Bessa Vilhena Andrês (2019-). Aged human bone rehabilitation with purinome-activated mesenchymal stromal cells: priming mechanism and pre-clinical validation. PhD Biomedical Sciences (ICBAS-UP). PhD Studentship from FCT (SFRH/BD/144613/2019).

6)     Qunatitive indicators (Research Gate). 1) Books (0); 2) Peer reviewed papers in international journals (183); 3) Book chapters (14); 4) Supervisor of MSc Thesis (54 completed); 5) Supervisor of PhD Thesis (17 completed); 6) Citations (>1980); RG score 41.23; h-Index 26.

7)     Links (e.g. MyResearcherID (ISI) or MyCitations (Google Scholar).

-      ORCID ID: 0000-0002-6114-9189

-      Scopus Author ID: 6603665744

-      ResearcherID: F-1079-2015

-      AuthenticusID: R-000-EFM

-      Loop profile: 6802

-      Ciência ID: 1C1B-40EC-3695

8)     Others

8.a) Scientific Prizes

-      Instituto de Ciências Biomédicas de Abel Salazar / BIAL (melhor aluno do curso 1982-88);

-      1º Prémio PFIZER para "Jovens Investigadores" (Soc. Ciências Médicas de Lisboa, 1990);

-      1º Prémio UCB de Farmacologia (Soc. Portuguesa de Farmacologia, melhor artigo de 1996);

-      1º Prémio “Silva Araújo” (XVII Jornadas de Terapêutica do ICBAS/HGSA, 2005);

-      Melhor comunicação livre (Soc. Portuguesa de Andrologia, 2006).

-      Melhor poster (PENS Summer Course, Kazan, Rússia, 2007).

-      Melhor poster (5ª Jornadas de Biologia na UTAD, Vila Real, Portugal 2011)

-      Comunicação selecionada (5 melhores) para representar a Universidade do Porto no SIICUSP (Universidade do Estado de S. Paulo – USP, S. Paulo, Brasil, Outubro de 2012).

-      Prémio Dr. Sousa Sampaio - “Mérito em Andrologia” (Tomar, Portugal 2012)

-      Melhor comunicação oral (7th YES Meeting 2012 FMUP - Sessão de Fisiologia e Imunologia (Porto, Portugal 2012).

-      EPHAR Poster Award Winner – 17th World Congress of Basic and Clinical Pharmacology (WCP 2014) (Cape Town, South Africa 2014).

-      Award for the Best Poster Presentation (Clinical Autonomic Neuroscience) - 9th Congress of the International Society for Autonomic Neuroscience – ISAN 2015 (Stresa, Itália 2015)

-      Prémio para o 2º Melhor Cartaz (valor de 500¤) – XI Congresso da Associação Portuguesa de Neurourologia e Uroginecologia (APNUG, Porto, Portugal 2017).

-          Prémio para a Melhor Comunicação Oral – X Jornadas de Genética e Biotecnologia (UTAD) (Vila Real, Portugal 2018).

-          Prémio Fundação Ernesto Morais, Melhor Comunicação Oral – 13th YES Meeting 2018 FMUP - Sessão de Fisiologia e Imunologia (Porto, Portugal 2018).

8.b) Scientific Societies Membership

-      Sociedade Portuguesa de Bioquímica / Neuroquímica (1986); Ordem dos Médicos (1988, Comissão Consultiva do Medicamento 2008); Sociedade Portuguesa de Farmacologia (1992, Vice-Presidente 2009-13, Presidente 2013- ); Sociedade Portuguesa de Neurociências (Sócio Fundador, 1993; Conselho Fiscal 2003-07); European Society for Neurochemistry (1993); International Society for Neurochemistry (1994); Federation of European Neuroscience Societies (1996); Sociedade Portuguesa de Ortopedia e Traumatologia (SPOT, 1998); International Society for Autonomic Neurosciences (ISAN, 2005); Purine and Pyrimidine Society - International Society for the Study on Purines and Pyrimidines in Man (2009).

8.c) Editoral Board Membership and Regular Reviewer

-     Biochemical Pharmacology (Gastrointestinal Pharmacology section – 2019-, Reviews Editor / Editorial Advisory Board); Frontiers in  Pharmacology (2015-, Associate Editor); International Journal of Pharmacological Sciences (2004-, Editorial Council); Saúde e Pesquisa (CESUMAR- Centro Universitário de Maringá, Paraná – Brasil) (2008-, Editorial Council).

-      Journal of Neurochemistry (1997-); Life Sciences (1998-); Journal of Pharmacology and Experimental Therapeutics (2002-); Comparative Biochemistry and Physiology (2003-); Comparative Hepatology (2003-); The Brazilian Journal of Medical and Biological Research (2004-); Biochemical Pharmacology (2004-);   Neuropharmacology (2006-); European Journal of Pharmacology (2007-); Journal of Alzheimer's Disease (2009-); Anesthesiology (2010-); British Journal of Pharmacology (2010-); Human Psychopharmacology: Clinical and Experimental (2010-); Journal of Cellular Physiology (2010-); Journal of Sexual Medicine (2010-); Muscle and Nerve (2010-); Clinical Experimental Pharmacology and Physiology (2011-); Journal of Agriculture and Food Chemistry (2011-); Pharmacological Research (2012-).

8.d) Publications in peer reviewed international journals (last 3 years) = 25 papers

-      A.R. Barros-Barbosa, A. Fonseca, S. Guerra-Gomes, F. Ferreirinha, A. Santos, R. Rangel, M.G. Lobo, P. Correia-de-Sá* & J.M. Cordeiro*. Up-regulation of P2X7 receptor-mediated inhibition of GABA uptake by nerve terminals of the human epileptic neocortex. Epilepsia (2016) 57: 99-110. doi: 10.1111/epi.13263.

-      N. Mañé*, R. Viais*, M. Martínez-Cutillas, D. Gallego, P. Correia-de-Sá & M. Jimenez. Inverse gradient of nitrergic and purinergic inhibitory co-transmission in the mouse colon. Acta Physiologica (Oxf) (2016) 216: 120-131. doi: 10.1111/apha.12599.

-      J.B. Noronha-Matos & P. Correia-de-Sá. Mesenchymal stem cells: targeting the “purinome” to promote osteogenic differentiation and bone repair. J. Cell. Physiol. (2016) 231: 1852-61 (“Mini-review”). doi: 10.1002/jcp.25303.

-      A. Lobo-Pimentel, G. Castro-Prado, C.R. Ambiel, P. Correia-de-Sá & W. Alves-do-Prado. Atropine is more efficient than ZM241385 to reduce a drastic level of fade caused by cisatracurium at 50 Hz. Acta Sci. Health Sci. (2016, in press).

-      B. Bragança, N. Oliveira-Monteiro, F. Ferreirinha, P.A. Lima, M. Faria, A.P. Fontes-Sousa & P. Correia-de-Sá. Ion fluxes through K_Ca2 (SK) and Ca_v1 (L-type) channels contribute to chronoselectivity of adenosine A₁ receptor-mediated actions in spontaneously beating rat atria. Front. Pharmacol. (2016) 7: 45. March 2016. doi: 10.3389/fphar.2016.00045.

-      M. Silva-Ramos, I. Silva, J.C. Oliveira & P. Correia-de-Sá. Increased urinary adenosine triphosphate in patients with bladder outlet obstruction due to benign prostate hyperplasia. Prostate (2016) 76: 1353–1363. doi: 10.1002/pros.23207.

-      A.R. Barros-Barbosa, F. Ferreirinha, A. Oliveira, M. Mendes, M.G. Lobo, A. Santos, R. Rangel, J. Pelletier, J. Sévigny, J.M. Cordeiro & P. Correia-de-Sá. Adenosine A_2A receptor and ecto-5’-nucleotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE). Purinergic Signalling (2016) 12, 719-734. doi: 10.1007/s11302-016-9535-2.

-      S. Costa, P. Correia-de-Sá, M.J. Porto & L. Cainé. The use of laser microdissection in forensic sexual assault casework: Pros and cons compared to standard methods. J. Forensic Sci. (2017) 62, 998–1006. doi: 10.1111/1556-4029.13348.

-      M. Certal, A. Vinhas, A. Barros-Barbosa, F. Ferreirinha, M.A. Costa & P. Correia-de-Sá. ADP-induced Ca²⁺ signalling and proliferation of rat ventricular myofibroblasts depend on phospholipase C-linked TRP channels activation within lipid rafts. J. Cell. Physiol. (2017) 232, 1511-1526. doi: 10.1002/jcp.25656.

-      I. Silva, A.F. Costa, S. Moreira, F. Ferreirinha, M.T. Magalhães-Cardoso, I. Calejo, M. Silva-Ramos & P. Correia-de-Sá. Inhibition of cholinergic neurotransmission by β₃-adrenoceptors depends on adenosine release and A₁ receptors activation in human and rat urinary bladders. Am. J. Physiol. – Renal Physiol. (2017) 313, F388-F403. doi: 10.1152/ajprenal.00392.2016.

-      P.B. Mello-Carpes, L.S. Vargas, R. Gonçalves, M.V.S. Lara, Z. Costa-Ferro, S. Salamoni, M. Domingues, A.R. Piovesan, D. Assis, L. Vinade, A.P. Corrado, W. Alves-do-Prado, P. Correia-de-Sá, J. Costa-da-Costa, I.A. Izquierdo, C.A. Dal Belo. Methylprednisolone as a memory enhancer in rats: effects on aversive memory, long-term potentiation and calcium influx. Brain Res. (2017) 1670, 44–51. doi:10.1016/j.brainres.2017.06.007.

-      W.L.G. Cavalcante, J.B. Noronha-Matos, M.A. Timóteo, M.R. de Mattos-Fontes, M. Gallacci & P. Correia-de-Sá. Neuromuscular paralysis by the basic phospholipase A₂ subunit of crotoxin from Crotalus durissus terrificus snake venom needs its acid chaperone to concurrently inhibit acetylcholine release and produce muscle blockage. Toxicol. Appl. Pharmacol (2017) 334, 8-17. doi: 10.1016/j.taap.2017.08.021.

-      C. Vieira, F. Ferreirinha, M.T. Magalhães-Cardoso, I. Silva, P. Marques & P. Correia-de-Sá. Postinflammatory ileitis induces non-neuronal purinergic signaling adjustments of cholinergic neurotransmission in the myenteric plexus. Front. Pharmacol. – Exp. Pharmacol. Drug Discov. – Purinergic Pharmacology (2017) 8, 811. doi: 10.3389/fphar.2017.00811.

-      S. Costa, G. Lima, P. Correia-de-Sá, M.J. Porto & L. Cainé. Assessment of DNA and mtDNA degradation in sperm cells collected by laser micro-dissection. J. Forensic. Res. (2017) 8, 393. doi: 10.4172/2157-7145.1000393.

-      A.R. Barros-Barbosa, A. Oliveira, M.G.B. Lobo, J.M. Cordeiro & P. Correia-de-Sá. Under stressful conditions activation of the ionotropic P2X7 receptor differentially regulates GABA and glutamate release from nerve terminals of the rat cerebral cortex. Neurochem. Int. (2018) 112, 81-95. doi: 10.1016/j.neuint.2017.11.005.

-      M. Bessa-Gonçalves*, B. Bragança*, E. Martins-Dias, P. Correia-de-Sá & A.P. Fontes-Sousa. Is the adenosine A2B “biased” receptor a valuable target for the treatment of pulmonary arterial hypertension? Drug Discovery Today (2018) 23, 1285-1292. doi: 10.1016/j.drudis.2018.05.005.

-      L. Figueira, C. Janeiro, F. Ferreirinha, P. Serrão, S. Perestrelo, F. Falcão-Reis, P. Correia-de-Sá & D. Moura. Regulation of corneal noradrenaline release and topography of sympathetic innervation: Functional implications for adrenergic mechanisms in the human cornea. Exp. Eye Res. (2018) 174, 121-132. doi: 10.1016/j.exer.2018.05.023.

-      L.M. Castellão-Santana, P.Y. Abiko, C.R. Ambiel, A.R. Peixoto, J.B. Noronha-Matos, P. Correia-de-Sá & W. Alves-Do-Prado. Tetanic facilitation of neuromuscular transmission by adenosine A_2A and muscarinic M₁ receptors is dependent on the uptake of choline via high-affinity transporters.  Pharmacology (2019) 103, 38-49. doi: 10.1159/000494058.

-          B. Bragança, S. Nogueira-Marques, F. Ferreirinha, A.P. Fontes-Sousa & P. Correia-de-Sá. The ionotropic P2X4 receptor has unique properties in the heart by mediating the negative chronotropic effect of ATP while increasing the ventricular inotropy. Front. Pharmacol. - Exp Pharmacol. Drug Disc. – Emerging Mechanisms in Purinergic Signaling: from Cell Biology to Therapeutic Perspectives (2019) 10, 1103. doi: 10.3389/fphar.2019.01103

-          A.O. Mocumbi, J.R. Stothard, P. Correia-de-Sá & M. Yacoub. Endomyocardial fibrosis: an update after 70 years. Curr. Cardiol. Rep. (2019) 21, 148. doi: 10.1007/s11886-019-1244-3.

-          R. Pinto-Cardoso, F. Pereira-Costa, J.P. Faria, P. Bandarrinha, C. Bessa-Andrês, P. Correia-de-Sá & J.B. Noronha-Matos. Adenosinergic signaling in chondrogenesis and cartilage homeostasis: Friend or foe? Biochem. Pharmacol - Commentary Review Article (2019) 174, 113784. doi: 10.1016/j.bcp.2019.113784.

-          M. Silva-Ramos*, I. Silva*, M. Faria, F. Ferreirinha & P. Correia-de-Sá. Activation of prejunctional P2X2/3 heterotrimers by ATP enhances the cholinergic tone in obstructed human urinary bladders. J. Pharmacol. Exp. Therap. (2020) 372, 63-72. doi: 10.1124/jpet.119.261610

-          I. Silva, M.T. Magalhães-Cardoso, F. Ferreirinha, S. Moreira, A.F. Costa, D. Silva, C. Vieira, M. Silva-Ramos & P. Correia-de-Sá. β₃ Adrenoceptor-induced cholinergic inhibition in human and rat urinary bladders involves the exchange protein directly activated by cyclic AMP 1 favoring adenosine release. Br. J. Pharmacol. (2020) 177, 1589-1608. doi: 10.1111/bph.14921

-          C. Herman-de-Sousa, A.R. Pinheiro, D. Paramos-de-Carvalho, M.A.Costa, F. Ferreirinha, M.T. Magalhães-Cardoso, S. Ribeiro, J. Pelletier, J. Sévigny & P. Correia-de-Sá. Opposing effects of adenosine and inosine in human subcutaneous fibroblasts may be regulated by third party ADA cell providers. Cells (2020) 9, 651. doi: 10.3390/cells9030651

-          J.B. Noronha-Matos, L. Oliveira, A.R. Peixoto, L. Almeida, L. Castellão-Santana, C.R. Ambiel, W. Alves-do Prado & P. Correia-de-Sá. Nicotinic α7 receptor-induced adenosine release from perisynaptic Schwann cells controls acetylcholine spillover from motor endplates. J Neurochem. (2020) Feb 3: e14975. doi: 10.1111/jnc.14975.