Molecular and Cellular Pharmacology

Code:

CF4000

Acronym:

CF4000

Keywords
Classification	Keyword
OFICIAL	Pharmacological Sciences

Instance: 2021/2022 - 2S

Active?	Yes
Responsible unit:	Imuno-Physiology and Pharmacology
Course/CS Responsible:	Master in Biochemistry

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
M:BQ	24	Plano de Estudos do MBIOQ_2013-2014	1	-	6	56	162

Teaching language

Suitable for English-speaking students

Objectives

Molecular and Cellular Pharmacology curriculum aims at increasing the students’ scientific knowledge on drugs action mechanisms, in a multidisciplinary scientific perspective privileging the research work at the laboratory level.

Learning outcomes and competences

The syllabus was defined so as to meet the main objective of the curricular unit. Consequently, it is structured so as to approach, in a comprehensive and practical manner, the study of pharmacology from a multidisciplinary and complementary point of view.

Working method

Presencial

Program

Introduction to Pharmacology – Clinical Trials - Pharmacogenetics & Pharmacogenomics – Pharmacokinetics: Absorption & distribution - Pharmacokinetics: Metabolization & Excretion- Kinetics of drug-receptor interaction – Methods in drug-receptor interaction analyses – Signalling transduction mechanisms and regulation- Synapses & neuroeffector junctions: Aminoacids; Acetylcholine; Catecholamines; 5-HT e Histamine; Peptides – Drugs action on metalloenzymes – Drugs action on microtubules and nucleic acid biosynthesis – Drugs action on anaerobic microorganisms metabolism – Drugs action on bacterial cell wall – Drugs action on steroids biosynthesis – Drugs action on PGs and LTs synthesis- Drugs action on cell membrane: gCa2+ - Drugs action on cell membrane: gNa+ - Drugs action on cell membrane: gK+ - Drugs action on cell membrane: ATPase

Mandatory literature

Rang H. P. 070; Pharmacology. ISBN: 0-443-07145-4

Complementary Bibliography

Goodman Louis Sanford 340; Goodman and Gilman.s the pharmacological basis of therapeutics. ISBN: 0-08-040296-8

Comments from the literature

- Goodman & Gilman’s The Pharmacological Basis of Therapeutics. J.G. Hardman & L.E. Limbird, 11thEd.,  McGraw-Hill, 2005.

- Basic and Clinical Pharmacology. B.G. Katzung, 10thEd., Lange, 2007.

- Rang and Dale’s Pharmacology. H.P. Rang, M.M. Dale, J.M. Ritter & R.J. Flower, 6thEd.,           Churchill Livinstone, 2007.

- Principles of Pharmacology – The pathophysiology Basis of Drug Therapy. D.E. Golan, A.H. Tashjian, E.J. Armstrong & A.W. Armstrong, 2thEd., Lippincott, Williams & Wilkins, 2008.

- Pharmacology. G.M. Brenner & C.W. Stevens, 2thEd., Saunders, 2006.

- Terapêutica Medicamentosa e suas Bases Farmacológicas. S. Guimarães, D. Moura e P. Soares da Silva, 5ª Ed., Porto Editora, 2006.

Teaching methods and learning activities

The methodology of learning includes theoretical, theoretical-practical and practical classes, as the following:

Theoretical lessons: Video projection (Data-Show).

Theoretical-Practical lessons: Presentation and discussion of themes/monographs related to the laboratory work (autonomous work) .

Practical lessons: Focus on experimental work at the Laboratory of Pharmacology (ICBAS).

Attendance to theoretical/practical and practical classes is compulsory.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	70,00
Trabalho escrito	15,00
Trabalho laboratorial	15,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Apresentação/discussão de um trabalho científico	28,00
Estudo autónomo	50,00
Frequência das aulas	28,00
Trabalho escrito	28,00
Trabalho laboratorial	28,00
Total:	162,00

Eligibility for exams

Practical-Evaluation (required component; 6 points):

1. Monograph/Theme presentation (4 points): Oral presentation of a new/relevant matter of importance to laboratory work and to clinical practice. Presentation of a written piece of work (monograph). Team work (3-4 students). Oral presentation (» 20 min) and oral discussion (» 10 min)
2.  Presentation of practical work (sorted group). Practical report. Tutor’s continual assessement.

NOTE: Practical-Evaluation approval is valid for two consecutive academic years.

Theoretical evaluation (required component; 14 points, written and oral exam)

Written test with multiple choice questions/cross answers questions + written short questions. Conditions for admission: *75% of attendance to theoretical and practical classes, *3.0/6.0 points in the practical course.

Oral exam: exemption of oral test with final grade/mark: * 7.5/14.0 points in the written exam. Conditions for admission to the oral test: * 6.0/14.0 points in the final written exam.

NOTE: Taking the final exams (written test + oral exam) at any time requires mandatory pre-registration 72 hours before taking the exams.

Calculation formula of final grade

Final Score = 0.3*practical score + 0.7*theoretical score

Practical classes score = 0,2*monograph/theme + 0,1*Practical classes

Special assessment (TE, DA, ...)

Oral examination

Classification improvement

Written and oral examination

Observations

ADAPTATION OF STUDENT ASSESSMENT (CONTINGENCY PLAN COVID-19)

Criteria approved by MBIOQ's Scientific Committee and by the Pedagogical Council
 

Group assessment (“distance learning”): 8 points

Distribution of the classification:

• Practical lessons (1p group report) - 4/8 points
• Monographs (2.5p written work + 1.5v discussion) - 4/8 points

Individual assessment (“final written test in person, without oral exam”): 12 points

Distribution of the classification:

• 40 multiple choice quiz - 8/12 points
• 10 short answer questions - 4/12 points

Final approval implies having at least 50% of the maximum grade in each of the two components. In special situations, duly justified, including special seasons, the final exam will consist of an “oral exam”, which can be performed at a distance.

Practical grades are valid for two consecutive years.