Immunology

Code:

M211

Acronym:

IM

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2018/2019 - 1S

Active?	Yes
Responsible unit:	Imuno-Physiology and Pharmacology
Course/CS Responsible:	Integrated Masters Degree in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIM	224	Transition Study Plan (2018)	2	-	6	56	162

Teaching language

Portuguese

Objectives

1. Acquisition of knowledge on fundamental immunology, necessary for the understanding of the immune physiology and pathology in humans. 2. Acquisition of skills for a better understanding of basic and advanced bibliographic information in the area of immunology. 3. Acquisition of of skills for self-oriented study. 4. Improvement of communication skills regarding oral and written transmission of knowledge. 5. Improvement of laboratory skills. 6. Acquisition of skills and knowledge on specific immunological diagnostic techniques.

Learning outcomes and competences

1. Acquisition of knowledge on fundamental immunology, necessary for the understanding of the immune physiology and pathology in humans. 2. Acquisition of skills for a better understanding of basic and advanced bibliographic information in the area of immunology. 3. Acquisition of of skills for self-oriented study. 4. Improvement of communication skills regarding oral and written transmission of knowledge. 5. Improvement of laboratory skills. 6. Acquisition of skills and knowledge on specific immunological diagnostic techniques.

Working method

Presencial

Program

1. Introduction to the immune system. 1.1. General introduction to the immune system. 1.2. Overview of hematopoiesis 2. Innate Immunity 2.1. Effector mechanisms (phagocytic cells, complement, inflammation). 2.2. Pathogen-associated molecular patterns (PAMPs) and their recognition (PRRs). 3. Acquired immunity. Cellular and mollecular components of the immune system and antigen recognition. 3.1. Central and perypheral lymphiod organs. 3.2. MHC. Codification and antigen presentation. 3.3. Immunoglobulins. B-cell receptor (BCR). 3.4. Antigen-antibody reactions. 3.5. V(D)J recombination and generation of diversity in immunoglobulins and T-cell eceptor (TCR). Implications of this process in the diagnostisc of primary immunodrficiencies. 3.6. TCR, Structure and function. 4. Ontogeny and dinamics of lymphoid populations. 4.1. Ontogeny and activation of B-cells. 4.2. Maturation of T and NK cells. 4.3. Activation of T-cells and B-T-cell cooperation. 5. Effector Mechanisms. 5.1. Cytokines. Differentiation and function of T-cells. 5.2. Immune response during infection.5.3. Immunity at body surfaces 5.4. Vaccines. 6. The immune system in physiological and pathologycal conditions. 6.1. Hypersensitivity reactions. 6.2. Tolerance and autoimmunity. 6.3. Transplantation. 6.4. Primary and secondary immunodeficiencies. 6.5. Tumor immunity and implications for immunotherapy. 7. Immunological methods 7.1. Separation of human blood mononuclear cells 7.2. Morphology of lymphoid organs. 7.3. Production of monoclonal antibodies. 7.4. B-cell response to a mitogen. Measurement of serum immunoglobulins by using “Sandwich-ELISA”. 7.5. Genotyping MHC. 7.6. Flow cytometry 7.7. Immunopathology 7.8. Hipersensitivities. 7. 9. Discussion of clinical case studies.

Mandatory literature

Abul K. Abbas, Andrew H. H. Lichtman, Shiv Pillai; Cellular and Molecular Immunology, Elsevier, 2017. ISBN: ISBN: 9780323479783

Teaching methods and learning activities

Theoretical classes. Laboratory classes and oral discussions

keywords

Health sciences > Medical sciences > Medicine > Immunology

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	100,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	106,00
Frequência das aulas	56,00
Total:	162,00

Eligibility for exams

Attaining of a minimum of 3/4 of the laboratory classes is necessary.

Calculation formula of final grade

Mark obtained on final exam or average of two parcial exams  A global mark of 9,5/20 is necessary for approval.

Examinations or Special Assignments

N/A

Internship work/project

N/A

Special assessment (TE, DA, ...)

According to the general law

Classification improvement

According to the general law