Molecular and Cellular Pharmacology

Code:

CF4000

Acronym:

CF4000

Keywords
Classification	Keyword
OFICIAL	Pharmacological Sciences

Instance: 2016/2017 - 2S

Active?	Yes
Responsible unit:	Imuno-Physiology and Pharmacology
Course/CS Responsible:	Master in Biochemistry

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
M:BQ	44	Plano de Estudos do MBIOQ_2013-2014	1	-	6	56	162

Teaching language

Portuguese

Objectives

Molecular and Cellular Pharmacology curriculum aims at increasing the students’ scientific knowledge on drugs action mechanisms, in a multidisciplinary scientific perspective privileging the research work at the laboratory level.

Learning outcomes and competences

The syllabus was defined so as to meet the main objective of the curricular unit. Consequently, it is structured so as to approach, in a comprehensive and practical manner, the study of pharmacology from a multidisciplinary and complementary point of view.

Working method

Presencial

Program

Introduction to Pharmacology – Clinical Trials - Pharmacogenetics & Pharmacogenomics – Pharmacokinetics: Absorption & distribution - Pharmacokinetics: Metabolization & Excretion- Kinetics of drug-receptor interaction – Methods in drug-receptor interaction analyses – Signalling transduction mechanisms and regulation- Synapses & neuroeffector junctions: Aminoacids; Acetylcholine; Catecholamines; 5-HT e Histamine; Peptides – Drugs action on metalloenzymes – Drugs action on microtubules and nucleic acid biosynthesis – Drugs action on anaerobic microorganisms metabolism – Drugs action on bacterial cell wall – Drugs action on steroids biosynthesis – Drugs action on PGs and LTs synthesis- Drugs action on cell membrane: gCa2+ - Drugs action on cell membrane: gNa+ - Drugs action on cell membrane: gK+ - Drugs action on cell membrane: ATPase

Mandatory literature

Rang H. P. 070; Pharmacology. ISBN: 0-443-07145-4

Complementary Bibliography

Goodman Louis Sanford 340; Goodman and Gilman.s the pharmacological basis of therapeutics. ISBN: 0-08-040296-8

Comments from the literature

- Goodman & Gilman’s The Pharmacological Basis of Therapeutics. J.G. Hardman & L.E. Limbird, 11thEd.,  McGraw-Hill, 2005.

- Basic and Clinical Pharmacology. B.G. Katzung, 10thEd., Lange, 2007.

- Rang and Dale’s Pharmacology. H.P. Rang, M.M. Dale, J.M. Ritter & R.J. Flower, 6thEd.,           Churchill Livinstone, 2007.

- Principles of Pharmacology – The pathophysiology Basis of Drug Therapy. D.E. Golan, A.H. Tashjian, E.J. Armstrong & A.W. Armstrong, 2thEd., Lippincott, Williams & Wilkins, 2008.

- Pharmacology. G.M. Brenner & C.W. Stevens, 2thEd., Saunders, 2006.

- Terapêutica Medicamentosa e suas Bases Farmacológicas. S. Guimarães, D. Moura e P. Soares da Silva, 5ª Ed., Porto Editora, 2006.

Teaching methods and learning activities

Distributed evaluation with final exam:

 

Practical and Theoretical-Practical (6 points): Compulsory attendance (2/3 of attendances). Continuous evaluation by the tutor.

 

Theory (14 points): Final examination (50 multiple choice quiz + 10 short answers) and/or oral examination (students must have >7.5/14.0 to succeed; compulsory between 6.0-7.5/14.0 points in the final examination).

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	70,00
Trabalho escrito	15,00
Trabalho laboratorial	15,00
Total:	100,00

Calculation formula of final grade

Practical Evaluation (6 points)

Theory evaluation (14 points)

Special assessment (TE, DA, ...)

Oral examination

Classification improvement

Written and oral examination