Immunology

Code:

MV224

Acronym:

IM

Keywords
Classification	Keyword
OFICIAL	Basic Sciences

Instance: 2014/2015 - 2S

Active?	Yes
Responsible unit:	Imuno-Physiology and Pharmacology
Course/CS Responsible:	Integrated Masters Degree in Veterinary Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMV	73	Plan 2007 to 2017	2	-	5	64	135

Teaching language

Portuguese

Objectives

1. Acquisition of knowledge and skills on fundamental immunology, emphasizing the particular specificities of different domestic animals. 2. Acquisition of skills helpful for a better understanding of basic and advanced bibliographic information in the area of immunology. 3. Acquisition and development of rational mechanisms useful for the interpretation of immunological data and resolution of immunological problems. 4. Acquisition of skills for self-oriented study, including the correct usage of specific databases. 5. Improvement of communication skills regarding oral and written transmission of knowledge. 6. Acquisition of skills and knowledge on specific immunological diagnostic techniques. 7. Improvement of laboratory skills.

Learning outcomes and competences

Working method

Presencial

Program

1. Introduction to the immune system. 1.1. General introduction to the immune system.

2. Innate Immunity 2.1. Effector mechanisms (phagocytic cells, complement, inflammation). 2.2. Pathogen-associated molecular patterns (PAMPs) and their recognition (PRRs).

3. Adaptive immunity. Cellular and mollecular components of the immune system and antigen recognition. 3.1. Central and perypheral lymphiod organs. Diffuse lymphoid tissue. 3.2. Hematopoietic development. 3.3. Immunoglobulins. B-cell receptor (BCR). 3.4. Antigen-antibody reactions. 3.5. V(D)J recombination and generation of diversity in immunoglobulins and T-cell eceptor (TCR). 3.6. TCR, Structure and function. 3.7. MHC. Antigen presentation.

4. Ontogeny and dinamics of lymphoid populations. 4.1. Ontogeny and activation of B-cells. 4.2. Maturation of T and NK cells. 4.3. Activation of T-cells and B-T-cell cooperation.

5. Effector Mechanisms. 5.1. Citokynes. Differentiation and function of T-cells. 5.2. Immune response during infection. 5.3. Immunity in body surfaces 5.4. Vaccines.

6. The immune system in physiological and pathologycal conditions. 6.1. Hypersensitivity reactions. 6.2. Tolerance and autoimmunity. 6.3. Transplantation. 6.4. Primary and secondary immunodeficiencies.

7. Immunologycal methods 7.1. Separation of human blood mononuclear cells 7.2. Morphology of lymphoid organs. 7.3. Production of monoclonal antibodies. 7.4. B-cell response to a mitogen. Measurement of serum immunoglobulins by using “Sandwich-ELISA”. 7.5. Immunopathology. 7.6. Flow cytometry 7.7. Analysis of Scientific problems.

Mandatory literature

Ian Tizard; Veterinary Immunology, Elsevier, 2013. ISBN: 1455703621

Teaching methods and learning activities

Theoretical classes , Laboratory classes, presentation of scientific papers by the students.

keywords

Health sciences > Medical sciences > Veterinary medicine > Animal immunology

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	75,00
Prova oral	15,00
Teste	10,00
Total:	100,00

Eligibility for exams

Participation in a minimum of 3/4 of the laboratory classes

Calculation formula of final grade

Sum of: Mark on theoretical tests or exam (up to 15) mark obtained on scientific papers presentations (up to 3,0) Active participation on classes along the year (oral or written) (up to 2,0). Minimum of 6,5 on each partial test necessary for approval

Examinations or Special Assignments

Oral paper presentations. Answers to written small questionnaires

Special assessment (TE, DA, ...)

According to general law, and specific rules approved by ICBAS

Classification improvement

According to general law, and specific rules approved by ICBAS

Observations

Lecturing will not be based or folow a given textbook. The recomended bibliography should thus be considered as complementary material to that presented in the course classess