Biological Chemistry I

Code:

MV117

Acronym:

QBI

Keywords
Classification	Keyword
OFICIAL	Basic Sciences

Instance: 2011/2012 - 1S

Active?	Yes
Responsible unit:	Chemistry
Course/CS Responsible:	Integrated Masters Degree in Veterinary Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMV	122	Plan 2007 to 2017	1	-	6	75	162

Teaching language

Portuguese

Objectives

1. To rationalize living systems in terms of basic Chemistry principles. To present Biological Chemistry as a mere subset of Chemistry.
2. To correlate knowledge from Organic and Inorganic Chemistry with Biological Chemistry.
3. To aquire specific knowledge about biological molecules and and cellular chemistry organization.

Program

Theoretical

1. Molecular structure
Chemical bond models, stereoisomery, molecular conformation.

2. Bioenergetics
Thermodynamics. Principles of thermodynamics. Gibbs function and chemical potential. Chemical equilibrium, application to Bronsted acid-base reactions. Energetics of redox reactions. Energetics of transport processes across biological membranes. Application of Thermodynamics Principles and Concepts to biological systems.

3. Bioinorganics
Metalic elements in biological systems: properties and regulation.

4. Bioorganics
Alkanes and cycloalkanes. Conformation and conformation analysis of alkanes and cycloalkanes. Conformation of cyclohexane. Reactions of free radicals.
Alkenes: Stability of Alkenes. Addition Reactions. Stability of carbocations. Electrophiles and nucleophiles. Regioselective reactions.
Stereochemistry and quiral molecules. Stereogenic carbons. Enantiomers and diastereoisomers. The R and S system. Optical activity. Fischer projection. Stereospecific reactions.

Laboratorial

1. Laboratorial techniques
2. Cromatography
3. Calorimetry
4. Potenciometric titration

Mandatory literature

T.W. Graham Solomons; Organic Chemistry, Jonh Wiley & Sons, Inc, 1998. ISBN: 4th Edition
D. L. Nelson and M.M.Cox; Lehninger, Principles of Biochemistry, Freeman, New York, 2005
P. W. Atkins and Julio de Paula; Physical Chemistry for the Life Sciences, W H Freeman & Co, 2006
Raymond Chang; Physical Chemistry for the Biosciences, University Science Books, Sausalito, 2005

Teaching methods and learning activities

Theoretical classes, using Powerpoint presentations. Theoretical-practical classes of problem solving and matters related with laboratorial works. Laboratorial classes where the students work in groups of up to 3, following a written protocol.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	0,00
	Total:	-	0,00

Calculation formula of final grade

Final mark (F), permited options:

Option 1: Partial assessments A3 and A4.
F = ( A1 + A2 ) / 2

Option 2: Exam E1.
F = E1

All assessments are composed of a theoretical evaluation (18 points) and a practical-theoretical evaluation (2 points).
Assessments A2 and E1 are mutually exclusive and occur simultaneously

Observations

Students are not allowed to enter the classes 10 minutes after its beggining time.

Adequate lab coats are mandatory in laboratorial classes.