Project: PTDC/BBB-BQB/1368/2014

Project name:	AQUAPORINAS - Aquaporins as molecular partners of CFTR in the the Blood-Testis Barrier: a crossroad between human male infertility and cystic fibrosis?
Project code:	PTDC/BBB-BQB/1368/2014
Proposing institution/Lead promoter/Coordinating entity:	Instituto de Ciências Biomédicas de Abel Salazar
Start date:	2016-06-15
Completion date:	2018-12-14

Eligible Cost of the Project

Total Eligible Cost:	167.857,00 EUR
Eligible Cost in the University of Porto:	167.857,00 EUR
Instituto de Ciências Biomédicas de Abel Salazar:	167.857,00 EUR

Total Financial Support

União Europeia - FEDER:

142.678,45 EUR

Financial Support to the University of Porto

Total of the University of Porto:	167.856,55 EUR
União Europeia \| União Europeia - FEDER \| Instituto de Ciências Biomédicas de Abel Salazar:	142.678,00 EUR
Nacional/Regional \| Orçamento de Estado \| Instituto de Ciências Biomédicas de Abel Salazar:	25.178,55 EUR

Objectives, activities and expected/achieved results

Objetivos e Atividades This proposal grounds on three main objectives: 1) to define the
physiological relevance of AQP9 in human SCs by assessing its intrinsic expression, regulation and function in SCs and throughout
the spermatogenic event; 2) to determine the role of CFTR on the transport activity of AQP9, by focalizing on the mechanism of the
possible reciprocal regulation between AQP9 and CFTR; 3) to investigate the relevance of AQP9 in the SCs and Sertoli/BTB glycerol
permeability as well as the on glycerolinduced
spermatogenic disruption as previous studies have shown that administration of low
levels of glycerol results in a marked reduction of spermatogenesis, accompanied by Sertoli/BTB disruption.

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