PVC MEMBRANE-ELECTRODE WITHOUT INNER REFERENCE SOLUTION FOR THE DIRECT DETERMINATION OF EPHEDRINE IN PHARMACEUTICAL PREPARATIONS

• Tipo: Artigo em Revista Científica Internacional
• Data: 1992

Autores

ALCADA, MNMP (Autor) Outra; LIMA, JLFC (Autor) FFUP; MONTENEGRO, MCB (Autor) FFUP

Revista

Título: Journal of Pharmaceutical and Biomedical Analysis

Vol. 10

Páginas: 757-761

ISSN: 0731-7085

Editora: Elsevier

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 15 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-001-P4T

DOI: 10.1016/0731-7085(91)80076-l

Abstract (EN): A PVC membrane electrode, without inner reference solution, based on an ion association extraction system responding to ephedrine is described. It incorporates an ephedrine-tetrakis (4-chlorophenyl)borate ion-pair complex in 2-nitrophenyloctyl ether. The prepared electrode exhibits a near Nernstian response (57.5 mV per decade) over the concentration range of 2 x 10(-5) 10(-1) M ephedrine in solutions of pH 2.5-9. The reproducibility of the electrode potentials were +/-1 mV by day during at least 6 months. Response time was about 6 s for ephedrine concentrations between 10(-5) and 10(-1) M. Determinations of ephedrine in pharmaceutical preparations (tablets, nasal drops and syrups) by direct potentiometry gave an average recovery of 99.1% (w/w) and a mean standard deviation of 1.9% (w/w).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5