Mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines

• Tipo: Capítulo ou Parte de Livro
• Data: 2022

Autores

Barbosa, DJ (Autor) Outra; Felix Carvalho (Autor) FFUP; Helena Carmo (Autor) FFUP

Livro

Título: Mitochondrial Intoxication

Páginas: 271-297

ISBN: 9780323884624

ISBN Eletrónico: 9780323884631

Editora: Elsevier

Indexação

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Y-5GW

DOI: 10.1016/b978-0-323-88462-4.00014-6

Abstract (EN): Amphetamines represent a class of widely abused psychotropic drugs. Methamphetamine, amphetamine, and 3,4-methylenedioxymethamphetamine (¿ecstasy¿) represent well-recognized examples, but the use of natural, amphetamine-like compounds, including cathinone derivates, has been part of the human history for thousands of years. A variety of acute and long-term adverse effects have been disclosed in drug abusers, including neurotoxicity, in which a major role for mitochondria dysfunction has been depicted. At this level, perturbations in enzymes of tricarboxylic acid cycle, inhibition of electron transport chain components, and oxidative modifications in mitochondrial macromolecules represent well reported mechanisms underlying the neurotoxicity of these drugs. In this chapter, the toxic effects of amphetamines at the mitochondrial level are reviewed. © 2023 Elsevier Inc. All rights reserved.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 26