The role of spray-drying atmosphere on fridericia chica (bonpl.) LG Lohmann standardized extract production for wound healing activity

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Sousa, IMD (Autor) Outra; Rivera, GA (Autor) Outra; Pinto, D (Autor) Outra; Queiroz, NDA (Autor) Outra; Bastos, VIC (Autor) Outra; Braga, LEO (Autor) Outra; Palmeira, JD (Autor) Outra; Amaral, H (Autor) Outra; Helena Sousa (Autor) FFUP; Oliveira, HCC (Autor) Outra; Goncalves, FJM (Autor) Outra; Ruiz, ALTG (Autor) Outra; Ibanez, E (Autor) Outra; Beatriz B P P Oliveira (Autor) FFUP; Foglio, MA (Autor) Outra

Revista

Título: Natural Product Research

Páginas: 1-5

ISSN: 1478-6419

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00V-W6D

DOI: 10.1080/14786419.2021.2012773

Abstract (EN): Fridericia chica (Bonpl.) L.G. Lohmann (synonym Arrabidaea chica Verlot) is widely used in Brazilian folk medicine. Considering overcoming pitfalls of scaling up production of plant extracts, herein the effects of N-2 atmosphere for extract spray-drying process is reported. Samples were monitored by in vitro antioxidant activity and microbiological evaluation. The drying atmosphere influenced 3-deoxyanthocyanines content when using air as atomizing gas, decreasing carajurin (37.5%) content with concomitant increase in luteolin yield (24.1%). Both drying processes preserved the pharmacological activity. In the cell migration test with HaCaT cells, the extract dried under air flow (5 mu g/mL) promoted wound closure by 78% (12 hours) whereas the extract dried using N-2 flow promoted 49% (12 hours), with 98% closure (12 hours) for the positive control. The antimicrobial evaluation for Staphylococcus aureus did not differ within drying atmospheres, with MIC (minimum inhibitory concentration) at 0.39 mg/mL. Therefore, the drying process reported herein did not interfere with the biological activity's outcome.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5