Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Matos, MJ (Autor) Outra; Labao Almeida, C (Autor) Outra; Sayers, C (Autor) Outra; Dada, O (Autor) Outra; Tacke, M (Autor) Outra; Bernardes, GJL (Autor) Outra

Revista

Título: Chemistry - A European Journal

Vol. 24

ISSN: 0947-6539

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 10 Citações

Outras Informações

ID Authenticus: P-00P-HEP

DOI: 10.1002/chem.201800872

Abstract (EN): Targeted delivery of potent cytotoxic drugs to cancer cells minimizes systemic toxicity and several side effects. NHC*-Au-Cl has already been proven to be a potent anticancer agent. In this study, we explore a strategy based on chemoselective cysteine conjugation of NHC*-Au-Cl to albumin and trastuzumab (Thiomab LC-V205C) to potentiate drug-ligand ratio, pharmacokinetics, as well as drug efficacy and safety. This strategy is a step forward towards the use of gold-based anticancer agents as targeted therapies.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4