The Use of Glycomacropeptide in Patients with Phenylketonuria: A Systematic Review and Meta-Analysis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Pena, MJ (Autor) Outra; Pinto, A (Autor) Outra; Daly, A (Autor) Outra; MacDonald, A (Autor) Outra; Azevedo L (Autor) FMUP; rocha, jc (Autor) Outra; Borges, Nuno (Autor) FCNAUP

Revista

Título: Nutrients

Vol. 10 Nº 11

Página Final: 1794

ISSN: 2072-6643

Editora: MDPI

Indexação

ISI Web of Knowledge - 29 Citações

Scopus - 30 Citações

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-00P-X51

DOI: 10.3390/nu10111794

Abstract (EN): In phenylketonuria (PKU), synthetic protein derived from L-amino acids (AAs) is essential in a low-phenylalanine (Phe) diet. Glycomacropeptide (GMP), an intact protein, is very low in Phe in its native form. It has been modified and adapted for PKU to provide an alternative protein source through supplementation with rate-limiting amino acids (GMP-AAs), although it still contains residual Phe. This review aims to systematically evaluate published intervention studies on the use of GMP-AAs in PKU by considering its impact on blood Phe control (primary aim) and changes in tyrosine control, nutritional biomarkers, and patient acceptability or palatability (secondary aims). Four electronic databases were searched for articles published from 2007 to June 2018. Of the 274 studies identified, only eight were included. Bias risk was assessed and a quality appraisal of the body of evidence was completed. A meta-analysis was performed with two studies with adequate comparable methodology which showed no differences between GMP-AAs and AAs for any of the interventions analysed. This work underlines the scarcity and nature of studies with GMP-AAs interventions. All were short-term with small sample sizes. There is a need for better-designed studies to provide the best evidence-based recommendations.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15