Chlamydia trachomatis infection: implications for HPV status and cervical cancer

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Silva, J (Autor) Outra; Cerqueira, F (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Vol. 289

Páginas: 715-723

ISSN: 0932-0067

Editora: Springer Berlin Heidelberg

Indexação

ISI Web of Knowledge - 103 Citações

Scopus - 113 Citações

Outras Informações

ID Authenticus: P-009-A6B

DOI: 10.1007/s00404-013-3122-3

Abstract (EN): Genital Chlamydia trachomatis (CT) infections have been identified as a major health problem concern. CT is associated with adverse effect on women reproduction and also associated with cervical hypertrophy and induction of squamous metaplasia, providing a possible relationship with human papillomavirus (HPV) infection. Infection by high-risk HPV types is crucial to the pathogenesis of invasive cervical cancer (ICC), but other co-variants/cofactors must be present for the development of malignancy. CT biological effect may damage the mucosal barrier, improving HPV infection, or may interfere in immune response and viral clearance supporting the persistence of HPV infection. Moreover, CT-related chronic cervical inflammation, decrease of lower genital tract antigen-presenting cells, inhibition of cell-mediated immunity, and anti-apoptotic capacity may influence the natural history of HPV infection, namely persistence progression or resolution. Although several epidemiological studies have stated a positive association involving CT and HPV-related cervical neoplastic lesions and/or cervical cancer (CC), the specific role of this bacterium in the pathogenesis of cervical neoplasia has not been completely clarified. The present review summarizes several studies on CT role in cervical cancer and suggests future research directions on HPV and CT interaction.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9