What is the effect of a Mediterranean compared with a Fast Food meal on the exercise induced adipokine changes? A randomized cross-over clinical trial

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Diana Silva (Author) Other; Rita Moreira (Author) Other; Marília Beltrao (Author) Other; Oksana Sokhatska (Author) Other; Tiago Montanha (Author) Other; Andreia Pizarro (Author) FADEUP; Vanessa Garcia-Larsen (Author) Other; Rodrigo Villegas (Author) Other; Luís Delgado (Author) Other; Pedro Moreira (Author) FCNAUP; Joana Carvalho (Author) FADEUP; André Moreira (Author) FMUP

Journal

Title: PLoS ONE

Vol. 14 No. 4

Pages: e0215475/1-0215475/15

ISSN: 1932-6203

Publisher: Public Library of Science

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Scientific classification

FOS: Social sciences

Other information

Authenticus ID: P-00Q-GBK

DOI: 10.1371/journal.pone.0215475

Abstract (EN): Background Adipose tissue-derived adipokines are pro-inflammatory cytokines involved in metabolic-related diseases and can be influenced by diet and exercise. We aimed to compare the effect of a Mediterranean (MdM) compared with Fast Food (FFM) meal on the exercise induced adipokines changes. Methods In a double blinded cross over trial, 46 participants were randomly assigned to one of two standardized iso-energy pre-exercise meals: FFM or MdM-type. Three hours after each meal, participants completed a treadmill exercise test (EC). Serum adiponectin, resistin, PAI-1, lipocalin-2/NGAL and adipsin were determined by Luminex magnetic bead immunoassay. Wilcoxon signed rank test compared changes before/after meal and before/after EC and a linear mixed model evaluated the effect of meals on the adipokine response to exercise, adjusted for confounders. Results Thirty-nine participants (mean age of 25, with a standard deviation of 5 years) completed the trial (56% females). For both interventions, a significant reduction of adipsin after each meal and a significant increase of lipocalin, PAI-1, adipsin and resistin, after exercise was observed. When exercise was preceded by a MdM meal a higher increase in adipsin levels was seen. Conclusion Acute exercise induced an increase of circulatory levels of adipsin, resistin, lipocalin and PAI-1, but not adiponectin. A pre-exercise Mediterranean meal potentiated the increase of adipsin after the exercise test, which possibly relates to the immune regulatory role of adipsin. These changes suggest a cross-talk between the immune and metabolic immediate response to exercise and its modulation by the pre-exercise diet composition.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15