The Elusive Nature of Adaptive Mitochondrial DNA Evolution of an Arctic Lineage Prone to Frequent Introgression

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Jose Melo Ferreira (Autor) Outra; Joana Vilela (Autor) Outra; Miguel M Fonseca (Autor) Outra; Rute R da Fonseca (Autor) Outra; Pierre Boursot (Autor) Outra; Paulo C Alves (Autor) FCUP

Revista

Título: Genome Biology and Evolution

Vol. 6

Páginas: 886-896

ISSN: 1759-6653

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 84 Citações

Scopus - 78 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências da terra e ciências do ambiente

Outras Informações

ID Authenticus: P-009-H9E

DOI: 10.1093/gbe/evu059

Abstract (EN): Mitochondria play a fundamental role in cellular metabolism, being responsible for most of the energy production of the cell in the oxidative phosphorylation (OXPHOS) pathway. Mitochondrial DNA (mtDNA) encodes for key components of this process, but its direct role in adaptation remains far from understood. Hares (Lepus spp.) are privileged models to study the impact of natural selection on mitogenomic evolution because 1) species are adapted to contrasting environments, including arctic, with different metabolic pressures, and 2) mtDNA introgression from arctic into temperate species is widespread. Here, we analyzed the sequences of 11 complete mitogenomes (ten newly obtained) of hares of temperate and arctic origins (including two of arctic origin introgressed into temperate species). The analysis of patterns of codon substitutions along the reconstructed phylogeny showed evidence for positive selection in several codons in genes of the OXPHOS complexes, most notably affecting the arctic lineage. However, using theoretical models, no predictable effect of these differences was found on the structure and physicochemical properties of the encoded proteins, suggesting that the focus of selection may lie on complex interactions with nuclear encoded peptides. Also, a cloverleaf structure was detected in the control region only from the arctic mtDNA lineage, which may influence mtDNA replication and transcription. These results suggest that adaptation impacted the evolution of hare mtDNA and may have influenced the occurrence and consequences of the many reported cases of massive mtDNA introgression. However, the origin of adaptation remains elusive.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11