Electroanalytical study of fluvoxamine

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Nouws, HPA (Autor) Outra; Delerue Matos, C (Autor) Outra; Barros, AA (Autor) FCUP; Rodrigues, JA (Autor) FCUP; Santos Silva, A (Autor) FFUP

Revista

Título: Analytical and Bioanalytical Chemistry

Vol. 382

Páginas: 1662-1668

ISSN: 1618-2642

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 17 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-000-1ZH

DOI: 10.1007/s00216-005-3310-5

Abstract (EN): Fluvoxamine (FVX) can be reduced at a mercury-drop electrode, with a maximum peak current intensity being obtained at a potential of -0.7 V vs. Ag/AgCl, in an aqueous electrolyte solution of pH 2. The compound was determined in a pharmaceutical product and in spiked human serum by square-wave adsorptive-stripping voltammetry (SWAdSV) after accumulation at the electrode surface, under batch conditions. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was also possible to determine FVX in the pharmaceutical product by use of a flow-injection analysis (FIA) system with SWAdSV detection. The methods developed were validated and successfully applied to the quantification of FVX in a pharmaceutical product. Recoveries between 76 and 89% were obtained in serum analysis. The FIA-SWAdSV method enabled analysis of up to 120 samples per hour at reduced cost, implying the possibility of competing with the chromatographic methods usually used for this analysis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7