Estrogen Signaling in Metabolic Inflammation

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

monteiro, rb (Autor) FCNAUP; teixeira, d (Autor) Outra; calhau, ca (Autor) Outra

Revista

Título: Mediators of Inflammation

Vol. 2014

Páginas: 1-20

ISSN: 0962-9351

Editora: Hindawi

Indexação

ISI Web of Knowledge - 51 Citações

Scopus - 81 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-009-Y6G

DOI: 10.1155/2014/615917

Abstract (EN): There is extensive evidence supporting the interference of inflammatory activation with metabolism. Obesity, mainly visceral obesity, is associated with a low-grade inflammatory state, triggered by metabolic surplus where specialized metabolic cells such as adipocytes activate cellular stress initiating and sustaining the inflammatory program. The increasing prevalence of obesity, resulting in increased cardiometabolic risk and precipitating illness such as cardiovascular disease, type 2 diabetes, fatty liver, cirrhosis, and certain types of cancer, constitutes a good example of this association. The metabolic actions of estrogens have been studied extensively and there is also accumulating evidence that estrogens influence immune processes. However, the connection between these two fields of estrogen actions has been underacknowledged since little attention has been drawn towards the possible action of estrogens on the modulation of metabolism through their anti-inflammatory properties. In the present paper, we summarize knowledge on the modification inflammatory processes by estrogens with impact on metabolism and highlight major research questions on the field. Understanding the regulation of metabolic inflammation by estrogens may provide the basis for the development of therapeutic strategies to the management of metabolic dysfunctions.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 20