Pharmaceutical trace analysis in aqueous environmental matrices by liquid chromatography-ion trap tandem mass spectrometry

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

madureira, tv (Autor) Outra; barreiro, jc (Autor) Outra; rocha, mj (Autor) ICBAS; cass, qb (Autor) Outra; M E Tiritan (Autor) FFUP

Revista

Título: Journal of Chromatography A

Vol. 1216 Nº 48

Páginas: 7033-7042

ISSN: 0021-9673

Editora: Elsevier

Indexação

ISI Web of Knowledge - 46 Citações

Scopus - 47 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-003-F0Y

DOI: 10.1016/j.chroma.2009.08.060

Abstract (EN): An analytical method based on solid-phase extraction followed by liquid chromatography tandem mass spectrometry with an ion trap analyser was developed and validated for the quantification of a series of pharmaceutical compounds with distinct physical-chemical characteristics in estuarine water samples. Method detection limits were between 0.03 and 16.4 ng/L The sensitivity and the accuracy obtained associated with the inherent confirmatory potential of ion trap tandem mass spectrometry (IT-MS/MS) validates its Success as an environmental analysis tool. Two MS/MS transitions were used to confirm compound identity. Almost all pharmaceuticals were detected at ng/L level in at least one sampling site of the Douro River estuary, Portugal.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10