Constitutive expression of Bcl-2 in the haematopoietic compartment alters the metabolism of iron and increases resistance to mycobacterial infection

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Florido, M (Autor) Outra; Borges, M (Autor) FFUP; Rodrigues, P (Autor) ICBAS; Vale Costa, S (Autor) Outra; Salome Gomes, M (Autor) ICBAS; Appelberg, R (Autor) ICBAS

Revista

Título: Clinical and Experimental Immunology

Vol. 156

Páginas: 61-68

ISSN: 0009-9104

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 0 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-003-KZP

DOI: 10.1111/j.1365-2249.2008.03867.x

Abstract (EN): Mice expressing a vav-bcl-2 transgene were tested for their resistance to an experimental infection with Mycobacterium avium. When compared with control littermates, transgenic mice exhibited an increase in the resistance to infection which was independent of B or T lymphocytes and did not require the production of gamma interferon. Macrophages from both control and transgenic mice showed equal permissiveness to M. avium growth in vitro. Finally, transgenic mice expressed diminished circulating iron levels which correlated with the increased resistance to infection.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8