Intragenic mutations in thyroid cancer

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2008

Autores

Manuel Sobrinho Simoes (Autor) FMUP; Valdemar Maximo (Autor) FMUP; Ana Sofia Rocha (Autor) Outra; Vitor Trovisco (Autor) Outra; Patricia Castro (Autor) FMUP; Ana Preto (Autor) Outra; Jorge Lima (Autor) FMUP; Paula Soares (Autor) FMUP

Revista

Título: Endocrinology and Metabolism Clinics of North America

Vol. 37

Páginas: 333-+

ISSN: 0889-8529

Editora: Elsevier

Indexação

ISI Web of Knowledge - 78 Citações

Scopus - 83 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-003-YQM

DOI: 10.1016/j.ecl.2008.02.004

Abstract (EN): The close genotype-phenotype relationship that. characterizes thyroid oncology stimulated the authors to address this article by using a mixed, genetic and phenotypic approach. As such, this article addresses the following aspects of intragenic mutations in thyroid cancer: thyroid stimulating hormone receptor and guanine-nucleotide-binding proteins of the stimulatory family mutations in hyperfunctioning tumors; mutations in RAS and other genes and aneuploidy; PAX8-PPAR gamma rearrangements; BRAF mutations; mutations in oxidative phosphorylation and Krebs cycle genes in Hurthle cell tumors; mutations in succinate dehydrogenase genes in medullary carcinoma and C-cell hyperplasia; and mutations in TP53 and other genes in poorly differentiated and anaplastic carcinomas.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 31