Characterisation of the endocannabinoid system in rat haemochorial placenta

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Bruno M Fonseca (Autor) FFUP; Georgina Correia da Silva (Autor) FFUP; Anthony H Taylor (Autor) Outra; Patricia M W Lam (Autor) Outra; Timothy H Marczylo (Autor) Outra; Justin C Konje (Autor) Outra; Natercia A Teixeira (Autor) FFUP

Revista

Título: Reproductive Toxicology

Vol. 34

Páginas: 347-356

ISSN: 0890-6238

Editora: Elsevier

Indexação

ISI Web of Knowledge - 17 Citações

Scopus - 21 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-002-49M

DOI: 10.1016/j.reprotox.2012.05.036

Abstract (EN): Trophoblast cells that comprise the placenta play a crucial role in the complex cross-talk between fetus and maternal tissues. Although anandamide and 2-arachidonoylglycerol, the best studied endocannabinoids, affect trophoblast attachment and outgrowth, the functional significance of the endocannabinoid system in the development of placenta has not been established. We investigated the correlation between endocannabinoid levels and the pattern of expression of the receptors and metabolic enzymes of the endocannabinoid system during rat placental development. Here, we showed that all the endocannabinoid machinery is dynamically expressed in the functionally distinct basal and labyrinth zones of the rat placenta. Indeed, endocannabinoid levels are shown to increase with the progression of pregnancy. Together, these data support a role for the endocannabinoid system in normal placental function and evidence for a potential novel cellular target for the deleterious action of cannabis-derived compounds during the second half of pregnancy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10