Synthesis and NMR studies of novel chromone-2-carboxamide derivatives

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Alexandra Gaspar (Autor) Outra; Fernando Cagide (Autor) FCUP; Elias Quezada (Autor) FCUP; Joana Reis (Autor) Outra; Eugenio Uriarte (Autor) Outra; Fernanda Borges (Autor) FCUP

Revista

Título: Organic Magnetic Resonance

Vol. 51

ISSN: 0749-1581

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 7 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-005-1R1

Abstract (EN): Chromones are heterocyclic compounds of natural or synthetic origin that possess relevant pharmacological activities. Versatile functionalization of the chromone nucleus allows attaining of a chemical diversity suitable to perform structure-activity relationships in drug discovery and development programs. Accordingly, the synthesis and identification of novel chromone carboxamide derivatives with electron-donating and electron-withdrawing substituents in different positions of the exocyclic ring are reported in this work. Their complete structural characterization was performed using one-dimensional and two-dimensional resonance techniques. The data acquired are useful for a prompt analysis of related compounds that encompass our integrated medicinal chemistry sketch. Copyright (C) 2013 John Wiley & Sons, Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica