Voltammetric and DFT studies on viloxazine: Analytical application to pharmaceuticals and biological fluids

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Manuela M P J Garrido (Autor) Outra; Jorge M P J Garrido (Autor) Outra; Mario Esteves (Autor) Outra; Alice Santos Silva (Autor) FFUP; Paula P M Marques (Autor) Outra; Fernanda Borges (Autor) FFUP

Revista

Título: Electroanalysis

Vol. 20

Páginas: 1454-1462

ISSN: 1040-0397

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 15 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Físicas > Química > Química analítica

Outras Informações

ID Authenticus: P-003-YQH

DOI: 10.1002/elan.200804202

Abstract (EN): The oxidative behavior of viloxazine was studied at a glassy carbon electrode in different buffer systems using cyclic, differential pulse and square-wave voltammetry. The oxidation process was shown to be diffusion-controlled and irreversible over the studied pH. The voltammetric study of the model compounds, 2-ethoxyanisole and morpholine, associated with quantum mechanical (DFT) calculations, allowed to elucidate the oxidation mechanism of viloxazine. An analytical method was developed for the quantification of viloxazine using an acetate pH 5 buffer solution as a supporting electrolyte. A linear response was obtained in the range 7 to 45 mu M, with a detection limit of 0.8 mu M. Validation parameters such as sensitivity, precision and accuracy were evaluated. The proposed method was successfully applied to the determination of viloxazine in pharmaceutical formulations and in human serum. The results were statistically compared with those obtained through an established high-performance liquid chromatography technique, no significant differences having been found between the two methods.

Idioma: Inglês

Tipo (Avaliação Docente): Científica