Mutants of Listeria monocytogenes defective in in vitro invasion and cell-to-cell spreading still invade and proliferate in hepatocytes of neutropenic mice

• Tipo: Artigo em Revista Científica Internacional
• Data: 2000

Autores

Appelberg, R (Autor) ICBAS; Leal, IS (Autor) Outra

Revista

Título: Infection and Immunity

Vol. 68

Páginas: 912-914

ISSN: 0019-9567

Editora: American Society for Microbiology

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 6 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Infecções

Outras Informações

ID Authenticus: P-001-0XF

DOI: 10.1128/iai.68.2.912-914.2000

Abstract (EN): Listeria monocytogenes mutants defective in the actA gene, the plcB gene, and the inlA and inlB genes were less virulent when injected intravenously into BALB/c mice. The growth of these strains as well as of the virulent wild-type strains was increased by treating mice with a neutrophil-specific depleting monoclonal antibody, RB6-8C5. Histologic examination of the livers of the treated animals showed intrahepatocytic proliferation of the listeriae in all cases. Our data show that more than one pathway exists that allows L. monocytogenes to invade parenchymal cells. One pathway most likely involves the actA and plcB gene products, and a second one probably involves the internalins.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3