Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Henriques-Coelho, T (Autor) FMUP; Oliveira, SM (Autor) FMUP; Moura, RS (Autor) Outra; Roncon-Albuquerque R, Jr. (Autor) Outra; Neves, AL (Autor) Outra; Santos, M (Autor) Outra; Nogueira-Silva, C (Autor) Outra; La Fuente Carvalho, F (Autor) Outra; Brandão-Nogueira, A (Autor) FMUP; Correia-Pinto, J (Autor) Outra; Leite-Moreira, AF (Autor) FMUP

Revista

Título: Endocrinology

Vol. 149 Nº 9

Páginas: 4367-4373

ISSN: 0013-7227

Editora: Endocrine Society

Indexação

ISI Web of Knowledge - 35 Citações

ISI Web of Science

Scopus - 36 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-003-WF1

DOI: 10.1210/en.2008-0018

Abstract (EN): The pathogenesis of pulmonary hypertension (PH) includes an inflammatory response. Thymulin, a zinc-dependent thymic hormone, has important immunobiological effects by inhibiting various proinflammatory cytokines and chemokines. We investigated morphological and hemodynamic effects of thymulin administration in a rat model of monocrotaline (MCT)-induced PH, as well as the pattern of proinflammatory cytokine gene expression and the intracellular pathways involved. Adult Wistar rats received an injection of MCT (60 mg/kg, sc) or an equal volume of saline. One day after, the animals randomly received during 3 wk an injection of saline, vehicle (zinc plus carboxymethyl cellulose), or thymulin (100 ng/kg, sc, daily). At d 23-25, the animals were anesthetized for hemodynamic recordings, whereas heart and lungs were collected for morphometric and molecular analysis. Thymulin prevented morphological, hemodynamic, and inflammatory cardiopulmonary profile characteristic of MCT-induced PH, whereas part of these effects were also observed in MCT-treated animals injected with the thymulin's vehicle containing zinc. The pulmonary thymulin effect was likely mediated through suppression of p38 pathway.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7