Cribriform-Morular Variant of Papillary Thyroid Carcinoma Molecular Characterization of a Case With Neuroendocrine Differentiation and Aggressive Behavior

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Jose Cameselle Teijeiro (Autor) Outra; Lia P Menasce (Autor) Outra; Beng K Yap (Autor) Outra; Rovel J Colaco (Autor) Outra; Patricia Castro (Autor) FMUP; Ricardo Celestino (Autor) Outra; Clara Ruiz Ponte (Autor) Outra; Paula Soares (Autor) FMUP; Manuel Sobrinho Simoes (Autor) FMUP

Revista

Título: American Journal of Clinical Pathology

Vol. 131 Nº 1

Páginas: 134-142

ISSN: 0002-9173

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 41 Citações

Scopus - 61 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-003-P12

DOI: 10.1309/ajcp7uls0vsisbeb

Abstract (EN): We describe an especially aggressive case of cribriform-morular variant (C-MV) of papillary thyroid carcinoma (PTC) in a 42-year-old man with familial adenomatous polyposis who died with lung and brain metastases 17 months after thyroidectomy. The angioinvasive neoplasm combined a mixture Of trabecular, solid, cribriform, and follicular patterns of growth with CD10+ morules. Follicles were devoid of colloid, and the nuclear features typical of PTC were present in some areas and missing in others. Tumor cells were positive for thyroid transcription factor-1 and, in 40% of the tumoral mass, also were positive for chromogranin and synaptophysin and were negative for thyroglobulin and calcitonin. Strong nuclear staining for beta-catenin was found in all tumor cells, as was positivity for p53 and cyclin D1. In addition to the germline heterozygous APC Ex 2-3 duplication mutation, a somatic homozygous silent p. Thr1493Thr gene variant was found in the neoplastic cells along with RET/PTC rearrangement. This tumor represents the first case of C-MV of PTC showing neuroendocrine differentiation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9