The contribution of medial temporal lobe atrophy and vascular pathology to cognitive impairment in vascular dementia

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Bastos-Leite AJ (Autor) FMUP; van der Flier WM (Autor) Outra; van Straaten ECW (Autor) Outra; Staekenborg SS (Autor) Outra; Scheltens P (Autor) Outra; Barkhof F (Autor) Outra

Revista

Título: Stroke

Vol. 38 Nº 12

Páginas: 3182-3185

ISSN: 0039-2499

Editora: Wolters Kluwer Health

Indexação

ISI Web of Knowledge - 93 Citações

Scopus - 103 Citações

Pubmed / Medline

Classificação Científica

CORDIS: Ciências da Saúde > Neurociências > Neurologia ; Ciências da Saúde > Neurociências > Neuropsicologia

Outras Informações

ID Authenticus: P-004-66X

DOI: 10.1161/strokeaha.107.490102

Abstract (EN): Background and Purpose - Besides cerebrovascular disease, medial temporal lobe atrophy (MTA), a neuroimaging finding suggestive of degenerative pathology, has been shown in vascular dementia (VaD). However, it is unknown to what extent MTA contributes to the pattern of cognitive impairment observed in VaD. Therefore, our purpose was to investigate the relative contribution of cerebrovascular disease and MTA to cognitive impairment in patients fulfilling diagnostic criteria for VaD. Methods - We examined 590 patients ( 374 men; mean age, 73 years; standard deviation, 8) with probable VaD according to the National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et l'Enseignement en Neurosciences criteria at inclusion into a multicenter clinical trial. Cerebrovascular disease and the degree of MTA were evaluated by using MRI. Cognitive testing included the Mini-Mental State Examination, and the vascular dementia assessment scale. Results - On the basis of the operational definitions for the neuroimaging part of the National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et l'Enseignement en Neurosciences criteria, 485 (82.2%) patients had small vessel VaD and 153 (25.9%) had large vessel VaD. More than half (59.8%) of the patients had considerable MTA. Multiple linear regression analyses revealed that after correction for sex, age, education, and duration of dementia, neuropsychological tests showed that patients with higher grades of MTA or large vessel VaD had significantly worse general cognitive and executive functioning, whereas associations with small vessel disease were restricted to worse executive functioning. Conclusions - Both MTA and large vessel disease contribute to global cognitive impairment in VaD. Small vessel disease contributes to executive dysfunction.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4