Up-regulation of metabotropic glutamate receptor 3 mRNA expression in the cerebral cortex of monoarthritic rats

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

Neto F.L. (Autor) FMUP; Schadrack, J (Autor) Outra; Platzer, S (Autor) Outra; Zieglgansberger, W (Autor) Outra; Tolle, TR (Autor) Outra; Castro-Lopes J.M. (Autor) FMUP

Revista

Título: Journal of Neuroscience Research

Vol. 63 Nº 4

Páginas: 356-367

ISSN: 0360-4012

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 29 Citações

Scopus - 31 Citações

Classificação Científica

CORDIS: Ciências da Saúde > Neurociências > Neurobiologia

Outras Informações

ID Authenticus: P-000-WCP

DOI: 10.1002/1097-4547(20010215)63:4<356::aid-jnr1030>3.0.co;2-3

Abstract (EN): Metabotropic glutamate receptors (mGluR) have been shown to play a role in the modulation of acute and inflammatory pain. Additionally, we have recently detected time-dependent changes in the mRNA expression of several mGluR subtypes in thalamic nuclei of monoarthritic (MA) rats. In the present study, mGluR1, -3, -4, and -7 subtype mRNA expression was analyzed by in situ hybridization with radioactively labelled oligonucleotide probes in cerebral cortical regions of normal and MA rats at 2, 4, and 14 days of the disease. The mGluR1, -4, and -7 mRNAs were at background level in normal rats and did not change in MA animals. In contrast, mGluR3 mRNA expression was abundant in normal rats and was significantly increased in cortical areas of MA rats at all time points. Higher changes were detected bilaterally at 4 days, predominantly in layers IV/V, in the motor, primary, and secondary somatosensory cortices (average increases of 50-75%), but maximum rises occurred in the contralateral cingulate cortex (+138%), No changes were detected in the auditory cortex. The present data show an up-regulation of mGluR3 mRNA expression in the motor, somatosensory, and limbic cortices of MA rats, This possibly reflects the occurrence of central mechanisms counteracting the increased transmission of nociceptive input arising from the inflamed paw and the impaired motor behavior of these rats. Changes in the cingulate cortex may be related to the motivational-affective component of nociception. (C) 2001 Wiley-Liss, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12