Parallel adaptation of rabbit populations to myxoma virus

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Alves, JM (Autor) Outra; Carneiro, M (Autor) Outra; Cheng, JY (Autor) Outra; de Matos, AL (Autor) Outra; Rahman, MM (Autor) Outra; Loog, L (Autor) Outra; Campos, PF (Autor) Outra; Wales, N (Autor) Outra; Eriksson, A (Autor) Outra; Manica, A (Autor) Outra; Strive, T (Autor) Outra; Graham, SC (Autor) Outra; Afonso, S (Autor) Outra; Bell, DJ (Autor) Outra; Belmont, L (Autor) Outra; Day, JP (Autor) Outra; Fuller, SJ (Autor) Outra; Marchandeau, S (Autor) Outra; Palmer, WJ (Autor) Outra; Queney, G (Autor) Outra; Surridge, AK (Autor) Outra; Vieira, FG (Autor) Outra; McFadden, G (Autor) Outra; Nielsen, R (Autor) Outra; Gilbert, MTP (Autor) Outra; Esteves, PJ (Autor) FCUP; ferrand, n (Autor) FCUP; Jiggins, FM (Autor) Outra

Revista

Título: Science

Vol. 363

Páginas: 1319-+

ISSN: 0036-8075

Editora: American Association for the Advancement of Science

Indexação

ISI Web of Knowledge - 93 Citações

Scopus - 97 Citações

Outras Informações

ID Authenticus: P-00Q-8H5

DOI: 10.1126/science.aau7285

Abstract (EN): In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein's antiviral effect.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 50