Understanding the dynamics of imipenem-resistant Acinetobacter baumannii lineages within Portugal

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Grosso, F (Autor) Outra; Quinteira, S (Autor) Outra; Peixe, L (Autor) FFUP

Revista

Título: Clinical Microbiology and Infection

Vol. 17 Nº 8

Páginas: 1275-1279

ISSN: 1198-743X

Editora: Elsevier

Indexação

ISI Web of Knowledge - 36 Citações

ISI Web of Science

Scopus - 41 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Ciências da saúde

Outras Informações

ID Authenticus: P-002-PAK

DOI: 10.1111/j.1469-0691.2011.03469.x

Resumo (PT): Clin Microbiol Infect 2011; 17: 1275-1279 Abstract A recent collection of 213 imipenem-resistant Acinetobacter baumannii (IRAB) clinical isolates was characterized for the presence of acquired carbapenem-hydrolysing class D β-lactamases (CHDLs) and clonality. A population structure analysis of IRAB was also conducted, with five molecular typing methods. Three main clusters, each one associated with a specific CHDL, were observed with multilocus sequence typing. Overall, our results suggest a switch in the dominant clone, with sequence type (ST) 92, carrying blaOXA-23 (63.4%), replacing the closely related ST98, carrying blaOXA-24/40 (22%). In addition, ST103, an independent lineage, was associated with blaOXA-58-carrying isolates (14.6%). <br> <br> Keywords: ACINETOBACTER *PATHOGENIC bacteria *CLONE cells *BETA lactamases. <br> <a target="_blank" href="http://web.ebscohost.com/ehost/detail?vid=7&hid=113&sid=a797790d-a87d-4eb5-bfc5-936e5299decf%40sessionmgr112&bdata=Jmxhbmc9cHQtYnImc2l0ZT1laG9zdC1saXZl#db=a9h&AN=63069458"> texto integral </a> <br> <br>

Abstract (EN): A recent collection of 213 imipenem-resistant Acinetobacter baumannii (IRAB) clinical isolates was characterized for the presence of acquired carbapenem-hydrolysing class D beta-lactamases (CHDLs) and clonality. A population structure analysis of IRAB was also conducted, with five molecular typing methods. Three main clusters, each one associated with a specific CHDL, were observed with multilocus sequence typing. Overall, our results suggest a switch in the dominant clone, with sequence type (ST) 92, carrying bla(OXA-23) (63.4%), replacing the closely related ST98, carrying bla(OXA-24/40) (22%). In addition, ST103, an independent lineage, was associated with bla(OXA-58)-carrying isolates (14.6%).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6