First Report on Cydonia oblonga Miller Anticancer Potential: Differential Anti proliferative Effect against Human Kidney and Colon Cancer Cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Marcia Carvalho (Autor) Outra; Branca M Silva (Autor) Outra; Renata Silva (Autor) Outra; Patricia Valentao (Autor) FFUP; Paula B Andrade (Autor) FFUP; Maria L Bastos (Autor) FFUP

Revista

Título: Journal of Agricultural and Food Chemistry

Vol. 58

Páginas: 3366-3370

ISSN: 0021-8561

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 39 Citações

ISI Web of Science

Scopus - 53 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências agrárias > Outras ciências agrárias

CORDIS: Ciências da Saúde > Ciências farmacológicas > Farmacognosia

Outras Informações

ID Authenticus: P-003-87E

DOI: 10.1021/jf903836k

Resumo (PT): The present study reports the phenolic profile and antiproliferative properties of quince (Cydonia oblonga Miller) leaf and fruit (pulp, peel, and seed) against human kidney and colon cancer cells. The phenolic profiles of quince methanolic extracts were determined by high-performance liquid chromatography (HPLC)/diode array detector (DAD). 5-O-Caffeoylquinic acid was always one of the two major phenolic compounds present in all extracts, except for seed. Our results revealed that quince leaf and fruit extracts exhibited distinctive antiproliferative activities. The extracts from quince leaf showed concentration-dependent growth inhibitory activity toward human colon cancer cells (IC50 = 239.7 ± 43.2 μg/mL), while no effect was observed in renal adenocarcinoma cells. Concerning the fruit, seed extracts exhibited no effect on colon cancer cell growth, whereas strong antiproliferative efficiency against renal cancer cells was observed for the highest concentration assayed (500 μg/mL). The antiproliferative activity of pulp and peel extracts was low or absent in the selected range of extract concentrations. This is the first report showing that C. oblonga may be useful as a cancer chemopreventive and/or chemotherapeutic agent. <br> <br> Keywords (keywords): Cydonia oblonga Miller; quince; phenolic compounds; antiproliferative activity; kidney cancer; colon cancer <br> <a target="_blank" href="http://pubs.acs.org/doi/abs/10.1021/jf903836k "> Texto integral</a> <br> <br>

Abstract (EN): The present study reports the phenolic profile and antiproliferative properties of quince (Cydonia oblonga Miller) leaf and fruit (pulp, peel, and seed) against human kidney and colon cancer cells. The phenolic profiles of quince methanolic extracts were determined by high-performance liquid chromatography (HPLC)/diode array detector (DAD). 5-O-Caffeoylquinic acid was always one of the two major phenolic compounds present in all extracts, except for seed. Our results revealed that quince leaf and fruit extracts exhibited distinctive antiproliferative activities. The extracts from quince leaf showed concentration-dependent growth inhibitory activity toward human colon cancer cells (IC(50) = 239.7 +/- 43.2 mu g/mL), while no effect was observed in renal adenocarcinoma cells. Concerning the fruit, seed extracts exhibited no effect on colon cancer cell growth, whereas strong antiproliferative efficiency against renal cancer cells was observed for the highest concentration assayed (500 mu g/mL). The anti proliferative activity of pulp and peel extracts was low or absent in the selected range of extract concentrations. This is the first report showing that C. oblonga may be useful as a cancer chemopreventive and/or chemotherapeutic agent.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5