The Biology of Cancer Exosomes: Insights and New Perspectives

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Ruivo, CF (Autor) Outra; Adem, B (Autor) Outra; Silva, M (Autor) Outra; Melo, SA (Autor) FMUP

Revista

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Título: CANCER RESEARCH

Vol. 77

Páginas: 6480-6488

ISSN: 0008-5472

Indexação

ISI Web of Knowledge - 291 Citações

Scopus - 302 Citações

Outras Informações

ID Authenticus: P-00N-A4Y

DOI: 10.1158/0008-5472.can-17-0994

Abstract (EN): Exosomes are a subclass of extracellular vesicles involved in intercellular communication that are released by all cell types, including cancer cells. Cancer exosomes carry malignant information in the form of proteins, lipids, and nucleic acids that can reprogram recipient cells. Exosomes have emerged as putative biological mediators in cancer contributing to major steps of disease progression. A leading role exists for cancer exosomes in specific aspects of tumor progression: modulation of immune response, tumor microenvironment reprogramming, and metastasis. This review will address the functions attributed to cancer exosomes in these three aspects of cancer biology, highlighting recent advances and potential limitations. Finally, we explore alternative strategies to develop better models to study cancer exosomes biology. (C) 2017 AACR.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9