Delayed Extensive Local Reaction to the mRNA-1273 Vaccine against SARS-CoV-2: A Case Report

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Ferreira-da-Silva, R (Autor) FMUP; Ribeiro-Vaz, I (Autor) FMUP; Silva, AM (Autor) FMUP; Nunes, F (Autor) Outra; Morato, M (Autor) Outra; Polonia, J (Autor) FMUP; Guedes, P (Autor) Outra

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS

Vol. 13

Páginas: 401-403

ISSN: 0976-500X

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00X-SVH

DOI: 10.1177/0976500x221147748

Abstract (EN): In response to the COVID-19 pandemic, two mRNA vaccines (Comirnaty and Spikevax) received emergency use authorization from the European Medicines Agency. This case report aimed to report a delayed adverse reaction to the mRNA-1273 vaccine against COVID-19 from a Portuguese vaccination center.A case report was performed with medical observation and reported to the Portuguese Pharmacovigilance System, then investigated based on the WHO-UMC Causality Categories. A 66-year-old female patient with a clinical history of dyslipidemia, essential arterial hypertension, obesity, multinodular goitre and cholecystectomy, who presented delayed large cutaneous hypersensitivity reaction following Spikevax COVID-19 mRNA (mRNA-1273) vaccine administration.Our clinical findings (time and clinical appearance), along with evidence of previously reported histological findings, are strongly suggestive of T-cell-mediated hypersensitivity. There is no contraindication to the inoculation of subsequent doses in patients developing these clinical conditions, and vaccination should continue to be strongly encouraged.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3